Argatroban Attenuates Diabetic Cardiomyopathy in Rats by Reducing Fibrosis, Inflammation, Apoptosis, and Protease-Activated Receptor Expression

Argatroban Attenuates Diabetic Cardiomyopathy in Rats by Reducing Fibrosis, Inflammation,... Purpose Chronic diabetes is associated with cardiovascular functional disturbances as evidenced from impaired cardiac dysfunctions. Diabetic cardiomyopathy (DCM) is one of the functional parameters and increased fibrosis. There was a sig- serious cardiovascular complications associated with diabetes. nificant increase in PAR expression after 20 weeks of diabetes Despite significant efforts in understanding the pathophysiol- induction. Four weeks argatroban treatment ameliorated met- ogy of DCM, management of DCM is not adequate due to its abolic alterations (reduced plasma glucose and cholesterol), complex pathophysiology. Recently, involvement of protease- ventricular dysfunctions (improved systolic and diastolic activated receptors (PARs) has been postulated in cardiovas- functions), cardiac fibrosis (reduced percentage area of colla- cular diseases. These receptors are activated by thrombin, gen in picro-sirius red staining), and apoptosis (reduced trypsin, or other serine proteases. Expression of PAR has been TUNEL positive nuclei). Reduced expression of PAR1 and shown to be increased in cardiac diseases such as myocardial PAR4 in the argatroban-treated group indicates a response infarction, viral myocarditis, and pulmonary arterial hyperten- towards inhibition of thrombin. In addition, AKT (Ser-473), sion. However, the role of PAR in DCM has not been eluci- GSK-3β (Ser-9), p-65 NFĸB phosphorylation, TGF-β,COX- dated yet. Therefore, in the present Cardiovascular Drugs and Therapy Springer Journals

Argatroban Attenuates Diabetic Cardiomyopathy in Rats by Reducing Fibrosis, Inflammation, Apoptosis, and Protease-Activated Receptor Expression

Loading next page...
Springer US
Copyright © 2017 by Springer Science+Business Media New York
Medicine & Public Health; Cardiology
Publisher site
See Article on Publisher Site


You’re reading a free preview. Subscribe to read the entire article.

DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches


Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.



billed annually
Start Free Trial

14-day Free Trial