Are more trials of calcium supplements really needed?

Are more trials of calcium supplements really needed? Osteoporos Int (2017) 28:2729–2730 DOI 10.1007/s00198-017-3988-1 LETTER 1,2 1 1 M. J. Bolland & A. Grey & I. R. Reid Received: 8 February 2017 /Accepted: 23 February 2017 /Published online: 7 July 2017 International Osteoporosis Foundation and National Osteoporosis Foundation 2017 Dear Editor, patient level meta-analysis [5]. If the unverified self-reports After an extensive review, Harvey et al. conclude that co- (all from the RECORD study [6]) are excluded, the hazard administered calcium and vitamin D supplements (but not ratio for myocardial infarction with calcium supplements calcium monotherapy) modestly reduces fractures, but that increases from 1.31 (95% confidence interval 1.02–1.67, calcium is associated with gastrointestinal side-effects and P = 0.035) to 1.44 (95% confidence interval 1.08–1.91, renal stones [1]. They concluded that there is inadequate P = 0.013). Furthermore, the authors accept that calcium evidence for cardiovascular side-effects of calcium supple- supplements increase the risk of kidney stones, even though ments and that a large randomized controlled trial (RCT) is these events were all self-reported, without independent required. verification [7]. Most of the authors’ concerns about analyses reporting The authors call for more large randomized controlled increased cardiovascular risk in RCTs of calcium supple- trials of calcium supplements. Six Osteoporosis International Springer Journals

Are more trials of calcium supplements really needed?

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Springer London
Copyright © 2017 by International Osteoporosis Foundation and National Osteoporosis Foundation
Medicine & Public Health; Orthopedics; Endocrinology; Rheumatology
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