Applying GRADE Criteria to Clinical Inputs to Cost-Effectiveness Modeling Studies

Applying GRADE Criteria to Clinical Inputs to Cost-Effectiveness Modeling Studies PharmacoEconomics (2018) 36:987–994 https://doi.org/10.1007/s40273-018-0651-4 ORIGINAL RESEARCH ARTICLE Applying GRADE Criteria to Clinical Inputs to Cost-Effectiveness Modeling Studies 1 2 2 2 • • • • Alexander Mensch Tanja Beck Daniele Civello Christopher Kunigkeit 2 2 3 2 • • • Nicole Lachmann Stephanie Stock Afschin Gandjour Dirk Mu ¨ ller Published online: 28 May 2018 Springer International Publishing AG, part of Springer Nature 2018 Abstract bias was found, and in about 30%, evidence was based on Background Concerns have been raised about the use of indirect clinical evidence, having significantly increased clinical data in cost-effectiveness models. The aim of this over the years. Study limitations were inadequately analysis was to evaluate the appropriate use of data on described in more than one third of the studies. However, clinical effectiveness in cost-effectiveness modeling stud- less than 10% of clinical studies showed inconsistency or ies that were published between 2001 and 2015. imprecision in study results. Methods Assessors rated 72 modeling studies obtained Conclusion Despite the fact that the majority of economic from three therapeutic areas by applying criteria defined by evaluations are based on precise and consistent randomized the Grading of Recommendations Assessment, Develop- controlled trials, their results are often http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png PharmacoEconomics Springer Journals

Applying GRADE Criteria to Clinical Inputs to Cost-Effectiveness Modeling Studies

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Publisher
Springer International Publishing
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Pharmacoeconomics and Health Outcomes; Quality of Life Research; Health Economics; Health Administration; Public Health
ISSN
1170-7690
eISSN
1179-2027
D.O.I.
10.1007/s40273-018-0651-4
Publisher site
See Article on Publisher Site

Abstract

PharmacoEconomics (2018) 36:987–994 https://doi.org/10.1007/s40273-018-0651-4 ORIGINAL RESEARCH ARTICLE Applying GRADE Criteria to Clinical Inputs to Cost-Effectiveness Modeling Studies 1 2 2 2 • • • • Alexander Mensch Tanja Beck Daniele Civello Christopher Kunigkeit 2 2 3 2 • • • Nicole Lachmann Stephanie Stock Afschin Gandjour Dirk Mu ¨ ller Published online: 28 May 2018 Springer International Publishing AG, part of Springer Nature 2018 Abstract bias was found, and in about 30%, evidence was based on Background Concerns have been raised about the use of indirect clinical evidence, having significantly increased clinical data in cost-effectiveness models. The aim of this over the years. Study limitations were inadequately analysis was to evaluate the appropriate use of data on described in more than one third of the studies. However, clinical effectiveness in cost-effectiveness modeling stud- less than 10% of clinical studies showed inconsistency or ies that were published between 2001 and 2015. imprecision in study results. Methods Assessors rated 72 modeling studies obtained Conclusion Despite the fact that the majority of economic from three therapeutic areas by applying criteria defined by evaluations are based on precise and consistent randomized the Grading of Recommendations Assessment, Develop- controlled trials, their results are often

Journal

PharmacoEconomicsSpringer Journals

Published: May 28, 2018

References

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