PharmacoEconomics (2018) 36:987–994 https://doi.org/10.1007/s40273-018-0651-4 ORIGINAL RESEARCH ARTICLE Applying GRADE Criteria to Clinical Inputs to Cost-Effectiveness Modeling Studies 1 2 2 2 • • • • Alexander Mensch Tanja Beck Daniele Civello Christopher Kunigkeit 2 2 3 2 • • • Nicole Lachmann Stephanie Stock Afschin Gandjour Dirk Mu ¨ ller Published online: 28 May 2018 Springer International Publishing AG, part of Springer Nature 2018 Abstract bias was found, and in about 30%, evidence was based on Background Concerns have been raised about the use of indirect clinical evidence, having signiﬁcantly increased clinical data in cost-effectiveness models. The aim of this over the years. Study limitations were inadequately analysis was to evaluate the appropriate use of data on described in more than one third of the studies. However, clinical effectiveness in cost-effectiveness modeling stud- less than 10% of clinical studies showed inconsistency or ies that were published between 2001 and 2015. imprecision in study results. Methods Assessors rated 72 modeling studies obtained Conclusion Despite the fact that the majority of economic from three therapeutic areas by applying criteria deﬁned by evaluations are based on precise and consistent randomized the Grading of Recommendations Assessment, Develop- controlled trials, their results are often
PharmacoEconomics – Springer Journals
Published: May 28, 2018
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