Mammalian Genome 13, 299–301 (2002). DOI: 10.1007/s00335-001-1022-5 Incorporating Mouse Genome © Springer-Verlag New York Inc. 2002 Application of interval haplotype analysis facilitates efficient mapping of the mutation causing osteopetrosis in tl rats 1 2 1, 1, 3 Elaine F. Remmers, Carl T. Hansen, Akira Hashiramoto, * Ronald L. Wilder, ** David E. Dobbins Inflammatory Joint Diseases Section, Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, 9000 Rockville Pike, Building 10/Room 9N228, Bethesda, MD 20892, USA Veterinary Resources Program, Office of Research Services, NIH, 9000 Rockville Pike, Building 14F/Room 101, Bethesda, MD 20892, USA Department of Anatomy, Physiology, and Genetics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814-4799, USA Received: 23 August 2001 / Accepted: 25 February 2002 Osteopetrosis is a manifest symptom of a heterogeneous group of osteopetrosis. Identification of these gene mutations is providing bone diseases that are characterized by an increase in skeletal mass an improved understanding of the molecular pathways involved in subsequent to inadequate osteoclastic bone resorption. A variety of the control of osteoclastic bone resorption (Benichou et al. 1998). genetic defects in animals and human have been shown to cause In the
Mammalian Genome – Springer Journals
Published: Feb 5, 2014
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