Reactions 1704, p48 - 2 Jun 2018 Major and minor bleed: 4 case reports In a study, two men and two women [ages not stated] were described, of whom, one man developed major bleed during direct oral anticoagulation (DOAC) therapy with rivaroxaban, and the remaining three patients developed minor bleed during DOAC therapy with apixaban. The patients had been receiving DOAC therapy with rivaroxaban 15mg once daily (1 patient), apixaban 2.5mg twice daily (2 patients) and apixaban 5mg twice daily (1 patient). Subsequently, the patient, who had been receiving rivaroxaban, developed major bleed (n=1) and the patients, who had been receiving apixaban, developed minor bleed (n=3) [times to reaction onsets and outcomes not stated]. Author comment: "Side-effects, listed in table 1, were common, ([rivaroxaban] 29.3%; [apixaban] 25.4%), although these were minor and transient in many cases." Nunn M, et al. Side-effects of doacs in middle-age (56-74 years). British Journal of Haematology 181 (Suppl. 1): 201-202 abstr. BSH18-EP-085, 16 Apr 2018. Available from: URL: https://doi.org/10.1111/bjh.15226 [abstract] - United Kingdom 803323437 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704
Reactions Weekly – Springer Journals
Published: Jun 2, 2018
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