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C Sumners, CH Gelband (1998)
Neuronal ion channel signalling pathways: modulation by angiotensin IICell Signal, 10
Y Ni, T Wang, X Zhuo, B Song, J Zhang, F Wei, H Bai, X Wang, D Yang, L Gao, A Ma (2013)
Bisoprolol reversed small conductance calcium-activated potassium channel (SK) remodeling in a volume-overload rat modelMol Cell Biochem, 384
YF Xu, D Tuteja, Z Zhang, DY Xu, Y Zhang, J Rodriguez, LP Nie, HR Tuxson, JN Young, KA Glatter, AE Vazquez, EN Yamoah, N Chiamvimonvat (2003)
Molecular identification and functional roles of a Ca2+-activated K+ channel in human and mouse heartsJ Biol Chem, 278
MA Schumacher, AF Rivard, HP Bachinger, JP Adelman (2001)
Structure of the gating domain of a Ca2+-activated K+ channel complexed with Ca2+/calmodulinNature, 410
Z Yang, T Qian, Z Wenjie (2006)
Influence of captopril on intracellular free calcium concentration and involved ion channels mechanisms in cardiac myocytes of the neonatal rat undergone anoxia- reoxygenation injuryChin J Pathophysiol, 22
J Zicha, L Paulis, Z Dobesova, J Kunes (2006)
Effects of captopril treatment on augmented norepinephrine-stimulated calcium entry through voltage-dependent calcium channels in spontaneously hypertensive ratsJ Hypertens, 24
S Nattel, A Maguy, S Bouter, Y-H Yeh (2007)
Arrhythmogenic ion-channel remodeling in the heart: Heart failure, myocardial infarction, and atrial fibrillationPhysiol Rev, 87
S-Y Wu, X Wang, Y Chen, J-X Pen, L Li, Y-F Qi, C-S Tang (2007)
The effect of angiotensin-converting enzyme inhibitors and aldosterone receptor blockers on cardiac function in calcium-overload ratsChin J Appl Physiol, 23
D Allen, B Fakler, J Maylie, JP Adelman (2007)
Organization and regulation of small conductance Ca2+-activated K+ channel multiprotein complexesJ Neurosci, 27
S-K Chua, P-C Chang, M Maruyama, I Turker, T Shinohara, MJ Shen, Z Chen, C Shen, M Rubart-von der Lohe, JC Lopshire, M Ogawa, JN Weiss, S-F Lin, T Ai, P-S Chen (2011)
Small-conductance calcium-activated potassium channel and recurrent ventricular fibrillation in failing rabbit ventriclesCirc Res, 108
C Dimitropoulou, C Snead, RE White, JD Catravas (2004)
Protein kinase C and protein phosphatase 2a mediate the angiotensin-induced stimulation of calcium- and voltage-dependent potassium channels in microvascular smooth muscle cellsFASEB J, 18
R Bai, L Wang, M Sun, N Liu, YF Ruan, CT Zhang (2008)
Knocking-down expression of delta-CAMK II by RNA interference attenuates angiotensin II-induced cardiomyocyte hypertrophy and intracellular calcium overloadEur Heart J, 29
A-T Ton, F Huynh, M Nemer, C Fiset (2014)
L-type calcium and potassium currents are differently regulated by angiotensin II in atrial and ventricular mouse myocytesBiophys J, 106
S Neubauer (2007)
Mechanisms of disease—the failing heart—an engine out of fuelN Engl J Med, 356
MY Zhu, CH Gelband, P Posner, C Sumners (1999)
Angiotensin II decreases neuronal delayed rectifier potassium current: role of calcium/calmodulin-dependent protein kinase IIJ Neurophysiol, 82
C Patton, S Thompson, D Epel (2004)
Some precautions in using chelators to buffer metals in biological solutionsCell Calcium, 35
IM Bonilla, VP Long, P Vargas-Pinto, P Wright, A Belevych, Q Lou, K Mowrey, J Yoo, PF Binkley, VV Fedorov, S Györke, PM Janssen, A Kilic, PJ Mohler, CA Carnes (2014)
Calcium-activated potassium current modulates ventricular repolarization in chronic heart failurePLoS One, 9
SA Doggrell, L Brown (1998)
Rat models of hypertension, cardiac hypertrophy and failureCardiovasc Res, 39
M Zhang, BL Prosser, MA Bamboye, ANS Gondim, CX Santos, D Martin, A Ghigo, A Perino, AC Brewer, CW Ward, E Hirsch, WJ Lederer, AM Shah (2015)
Contractile function during angiotensin-II activation increased Nox2 Activity Modulates Cardiac Calcium Handling via Phospholamban PhosphorylationJ Am Coll Cardiol, 66
T Krause, S Aleth, F Balzer, W Schmitz, J Neumann (2003)
Altered expression of cardiac PP2A in patients with end-stage heart failureNaunyn-Schmiedebergs Arch Pharmacol, 367
In heart failure (HF), the malignant arrhythmias occur frequently; a study demonstrated that upregulation of I KAS resulted in recurrent spontaneous ventricular fibrillation in HF. However, the regulation of SK channels was poorly understood. The activation of SK channels depended on [Ca2+]i and PP2A; studies suggested that angiotensin II can regulate them. So, we hypothesized that in HF, the excess of angiotensin may regulate the SK channels and result in the remodeling of SK channels. To test the hypothesis, we used volume-overload-induced HF rat model, treated with captopril, performed whole-cell patch clamp to record apamin-sensitive currents (I KAS), and I–V curve was studied. The sensitivity of I KAS to [Ca2+]i was also explored by setting various [Ca2+]i (10, 100, 500, 900, 1000, and 10,000 nM), and the steady-state Ca2+ response of I KAS was attained and performed Hill fitting with the equation (y = 1/[1 + (EC50/x) n ]). Immunofluorescent staining, real-time PCR, Western blot were also carried out to furtherly investigate the underlying molecular mechanisms of the regulation. Captopril significantly decreased the mean density of I KAS when [Ca2+]i was 500, 900, 1000, and 10000 nM. The Hill fitting showed significantly different EC50 values and the Hill coefficients and showed captopril significantly shifted rightward the steady-state Ca2+ response of I KAS. The results of real-time PCR and Western blot demonstrated captopril decreased the mRNA and protein expression of SK3 channels. Captopril significantly downregulated the sensitivity of SK channels to [Ca2+]i and the SK3 channels expression in HF, and reversed the SK channels remodeling.
The Journal of Membrane Biology – Springer Journals
Published: Feb 29, 2016
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