Antivirals

Antivirals Reactions 1680, p50 - 2 Dec 2017 Virological failure and acquired multi-antiviral resistance to HIV-1C infection: 26 case reports In a prospective cohort study of 320 patients, 15 women and 11 men aged between 25–51 years were described, who developed virological failure and acquired multi-antiviral resistance to antivirals during treatment of HIV-1C infection [routes and dosages not stated]. The patients, who had a history of HIV-1C infection, started receiving treatment with lamivudine, stavudine and nevirapine (9 patients), lamivudine, stavudine and efavirenz (1 patient), lamivudine, zidovudine and nevirapine (12 patients) and lamivudine, zidovudine and efavirenz (4 patients). After 5–8 years of antiviral treatments, the patients developed virological failure and acquired multi-antiviral drug resistance mutations, which were confirmed by genotypic susceptibility test [outcomes not stated]. Author comment: "This study describes a decade virological outcomes and measures the incidence of virological failure and acquired drug resistance mutations in Ethiopian HIV-1C infected adults at 4 time points from the Horn of Africa." Mulu A, et al. Upward trends of acquired drug resistances in Ethiopian HIV-1C isolates: A decade longitudinal study. PLOS One 12: e0186619, No. 10, Oct 2017. Available from: URL: http://doi.org/10.1371/journal.pone.0186619 - Ethiopia 803284108 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Antivirals

Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
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Publisher
Springer International Publishing
Copyright
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
D.O.I.
10.1007/s40278-017-38981-1
Publisher site
See Article on Publisher Site

Abstract

Reactions 1680, p50 - 2 Dec 2017 Virological failure and acquired multi-antiviral resistance to HIV-1C infection: 26 case reports In a prospective cohort study of 320 patients, 15 women and 11 men aged between 25–51 years were described, who developed virological failure and acquired multi-antiviral resistance to antivirals during treatment of HIV-1C infection [routes and dosages not stated]. The patients, who had a history of HIV-1C infection, started receiving treatment with lamivudine, stavudine and nevirapine (9 patients), lamivudine, stavudine and efavirenz (1 patient), lamivudine, zidovudine and nevirapine (12 patients) and lamivudine, zidovudine and efavirenz (4 patients). After 5–8 years of antiviral treatments, the patients developed virological failure and acquired multi-antiviral drug resistance mutations, which were confirmed by genotypic susceptibility test [outcomes not stated]. Author comment: "This study describes a decade virological outcomes and measures the incidence of virological failure and acquired drug resistance mutations in Ethiopian HIV-1C infected adults at 4 time points from the Horn of Africa." Mulu A, et al. Upward trends of acquired drug resistances in Ethiopian HIV-1C isolates: A decade longitudinal study. PLOS One 12: e0186619, No. 10, Oct 2017. Available from: URL: http://doi.org/10.1371/journal.pone.0186619 - Ethiopia 803284108 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680

Journal

Reactions WeeklySpringer Journals

Published: Dec 2, 2017

References

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