Reactions 1680, p50 - 2 Dec 2017
Virological failure and acquired multi-antiviral
resistance to HIV-1C infection: 26 case reports
In a prospective cohort study of 320 patients, 15 women
and 11 men aged between 25
51 years were described, who
developed virological failure and acquired multi-antiviral
resistance to antivirals during treatment of HIV-1C infection
[routes and dosages not stated].
The patients, who had a history of HIV-1C infection, started
receiving treatment with lamivudine, stavudine and nevirapine
(9 patients), lamivudine, stavudine and efavirenz (1 patient),
lamivudine, zidovudine and nevirapine (12 patients) and
lamivudine, zidovudine and efavirenz (4 patients). After
8 years of antiviral treatments, the patients developed
virological failure and acquired multi-antiviral drug resistance
mutations, which were confirmed by genotypic susceptibility
test [outcomes not stated].
Author comment: "This study describes a decade
virological outcomes and measures the incidence of
virological failure and acquired drug resistance mutations in
Ethiopian HIV-1C infected adults at 4 time points from the
Horn of Africa."
Mulu A, et al. Upward trends of acquired drug resistances in Ethiopian HIV-1C
isolates: A decade longitudinal study. PLOS One 12: e0186619, No. 10, Oct 2017.
Available from: URL: http://doi.org/10.1371/journal.pone.0186619 -
Reactions 2 Dec 2017 No. 16800114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved