Antiviral effect of lithium chloride on infection of cells by porcine parvovirus

Antiviral effect of lithium chloride on infection of cells by porcine parvovirus Porcine parvovirus (PPV) causes reproductive failure in pigs, which leads to economic losses to the industry. As reported previously, LiCl efficiently impairs the replication of a variety of viruses, including the coronavirus infectious bronchitis virus (IBV), transmissible gastroenteritis virus (TGEV), and pseudorabies herpesvirus. We demonstrate for the first time that inhibition of PPV replication in swine testis (ST) cells by LiCl is dose-dependent, and that the antiviral effect of LiCl occurred in the early phase of PPV replication. These results indicate that LiCl might be an effective anti-PPV drug to control PPV disease. Further studies are required to explore the mechanism of the antiviral effect of LiCl on PPV infection in vivo . http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Antiviral effect of lithium chloride on infection of cells by porcine parvovirus

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Publisher
Springer Vienna
Copyright
Copyright © 2015 by Springer-Verlag Wien
Subject
Biomedicine; Virology; Medical Microbiology; Infectious Diseases
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-015-2352-z
Publisher site
See Article on Publisher Site

Abstract

Porcine parvovirus (PPV) causes reproductive failure in pigs, which leads to economic losses to the industry. As reported previously, LiCl efficiently impairs the replication of a variety of viruses, including the coronavirus infectious bronchitis virus (IBV), transmissible gastroenteritis virus (TGEV), and pseudorabies herpesvirus. We demonstrate for the first time that inhibition of PPV replication in swine testis (ST) cells by LiCl is dose-dependent, and that the antiviral effect of LiCl occurred in the early phase of PPV replication. These results indicate that LiCl might be an effective anti-PPV drug to control PPV disease. Further studies are required to explore the mechanism of the antiviral effect of LiCl on PPV infection in vivo .

Journal

Archives of VirologySpringer Journals

Published: Apr 1, 2015

References

  • First complete genomic characterization of a porcine parvovirus 5 isolate from China
    Wu, R; Wen, Y; Huang, X; Wen, X; Yan, Q; Huang, Y; Ma, X; Cao, S
  • Identification and molecular cloning of a novel porcine parvovirus
    Cheung, AK; Wu, G; Wang, D; Bayles, DO; Lager, KM; Vincent, AL
  • Antiviral effect of diammonium glycyrrhizinate on cell infection by porcine parvovirus
    Li, P; Zou, H; Ren, Y; Zarlenga, DS; Ren, X

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