Antiviral effect of lithium chloride on infection of cells by canine parvovirus

Antiviral effect of lithium chloride on infection of cells by canine parvovirus Canine parvovirus type 2 causes significant viral disease in dogs, with high morbidity, high infectivity, and high mortality. Lithium chloride is a potential antiviral drug for viruses. We determined the antiviral effect of Lithium Chloride on canine parvovirus type 2 in feline kidney cells. The viral DNA and proteins of canine parvovirus were suppressed in a dose-dependent manner by lithium chloride. Further investigation verified that viral entry into cells was inhibited in a dose-dependent manner by lithium chloride. These results indicated that lithium chloride could be a potential antiviral drug for curing dogs with canine parvovirus infection. The specific steps of canine parvovirus entry into cells that are affected by lithium chloride and its antiviral effect in vivo should be explored in future studies. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Antiviral effect of lithium chloride on infection of cells by canine parvovirus

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Publisher
Springer Vienna
Copyright
Copyright © 2015 by Springer-Verlag Wien
Subject
Biomedicine; Virology; Medical Microbiology; Infectious Diseases
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-015-2577-x
Publisher site
See Article on Publisher Site

References

  • Antiviral effect of lithium chloride on infection of cells by porcine parvovirus
    Chen, YYH; Zheng, H; Shi, Y; Sun, L; Wang, C; Sun, J
  • Canine parvovirus infection: which diagnostic test for virus?
    Desario, C; Decaro, N; Campolo, M; Cavalli, A; Cirone, F; Elia, G; Martella, V; Lorusso, E; Camero, M; Buonavoglia, C
  • An enteric disease of dogs resembling feline panleucopaenia
    Kelly, W

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