Antitumor activity and safety profile of weekly carboplatin plus paclitaxel in metastatic breast cancer: a ten-year, monocentric, retrospective study

Antitumor activity and safety profile of weekly carboplatin plus paclitaxel in metastatic breast... Breast Cancer Res Treat (2017) 165:365–373 DOI 10.1007/s10549-017-4336-z CLINICAL TRIAL Antitumor activity and safety profile of weekly carboplatin plus paclitaxel in metastatic breast cancer: a ten-year, monocentric, retrospective study 1,2 1 1 1 • • • • Claudio Vernieri Monica Milano Alessia Mennitto Claudia Maggi 1 1 1 1 • • • • Benvenuto Ferrari Lucia Rinaldi Roberta Mennitto Claudia Stefanetti 3 1 1 1 • • • • Barbara Re Gabriella Mariani Giulia Bianchi Giuseppe Capri 1,4 Filippo de Braud Received: 5 June 2017 / Accepted: 8 June 2017 / Published online: 14 June 2017 Springer Science+Business Media, LLC 2017 Abstract HER2-negative biology, a higher number of metastatic Background Taxanes are a mainstay in the treatment of sites, and de novo metastatic disease at diagnosis were metastatic breast cancer (mBC). Combination chemother- associated with reduced PFS, while receiving mainte- apy, including platinum–taxens doublets, can improve nance therapy correlated with improved PFS. Overall, tumor responses and progression-free survival (PFS), but is the treatment was quite well tolerated, with 10.2% of associated with more toxicities and an uncertain benefit in patients discontinuing one or both drugs because of terms of overall survival (OS). adverse events (AEs). G3–G4 neutropenia occurred in http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Breast Cancer Research and Treatment Springer Journals

Antitumor activity and safety profile of weekly carboplatin plus paclitaxel in metastatic breast cancer: a ten-year, monocentric, retrospective study

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Publisher
Springer US
Copyright
Copyright © 2017 by Springer Science+Business Media, LLC
Subject
Medicine & Public Health; Oncology
ISSN
0167-6806
eISSN
1573-7217
D.O.I.
10.1007/s10549-017-4336-z
Publisher site
See Article on Publisher Site

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