Antituberculars Reactions 1680, p49 - 2 Dec 2017 Drug induced hepatitis: case report In a retrospective study, a 22-year-old woman developed drug induced hepatitis following treatment with isoniazid, rifampicin [rifampin], pyrazinamide and ethambutol (HRZE regimen) [dosages, routes, outcome and time to reaction onset not stated]. The woman presented with history of abdominal pain. She had intestinal obstruction. Mantoux skin test was positive. Fine needle aspiration revealed granuloma of the lymph nodes. Based on these findings, a probable diagnosis of tuberculosis was made. CT scan revealed tubercular abdominal cocoon (sclerosing encapsulating peritonitis). She started receiving anti-tubercular therapy (ATT) with isoniazid, rifampin, pyrazinamide and ethambutol. She developed hepatitis induced by ATT. She received treatment with ATT for 6 months. The woman’s anti-tubercular therapy was changed to levofloxacin, streptomycin and ethambutol. Author comment: "One patient needed modification in ATT due to dvelopment of ATT induced hepatitis." Sharma V, et al. Role of conservative management in tubercular abdominal cocoon: a case series. Infection 45: 601-606, No. 5, Oct 2017. Available from: URL: - India 803285411 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 Reactions Weekly Springer Journals


Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
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Springer International Publishing
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
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