Reactions 1704, p40 - 2 Jun 2018 Antiplatelets/dabigatran-etexilate/ ibrutinib Haematospermia and haematuria: 2 case reports In a retrospective analysis involving 74 patients, two patients [ages and sexes not stated] were described, one of the two patients developed haematospermia during treatment with ibrutinib and unspecified antiplatelet drugs, while the second patient developed haematuria during treatment with dabigatran etexilate [dabigatran] and ibrutinib [routes, dosages and durations of treatments to reactions onsets not stated, not all indications stated]. One of the two patients started receiving ibrutinib along with unspecified antiplatelet drugs, and the second patient started receiving dabigatran etexilate along with ibrutinib for atrial fibrillation. However, the patient who was receiving ibrutinib with unspecified antiplatelet drugs, developed transient grade II bleeding (haematospermia). Consequently, the patient discontinued the antiplatelet therapy, but continued ibrutinib without any further complications. The second patient who was receiving dabigatran etexilate with ibrutinib, developed grade II bleeding (haematuria). Thereafter, the patient’s dabigatran-etexilate therapy was discontinued, but ibrutinib was continued without any further complications [not all outcomes stated]. Author comment: "The drug [Ibrutinib] is associated with 6–10% risk of atrial fibrillation and an increased risk of bleeding. From the 12 patients receiving concomitant BTK inhibitors and either antiplatelet drugs or anticoagulation there were 2 cases of grade 2 bleeding." Mihailescu L, et al. The plymouth experience of bleeding complications associated with concomitant treatment with BTK inhibitors and anticoagulants or antiplatelet drugs. British Journal of Haematology 181 (Suppl. 1): 175 (plus poster) abstr. BSH18-EP-033, Apr 2018. Available from: URL: http://doi.org/10.1111/bjh.15226 [abstract] - United Kingdom 803323365 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704
Reactions Weekly – Springer Journals
Published: Jun 2, 2018
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