Russian Journal of Applied Chemistry, 2010, Vol. 83, No. 2, pp. 293−296.
Pleiades Publishing, Ltd., 2010.
Original Russian Text
A.V. Zamanova, M.M. Kurbanova, I.A. Rzaeva, V.M. Farzaliev, M.A. Allakhverdiev, 2010, published in Zhurnal Prikladnoi Khimii,
2010, Vol. 83, No. 2, pp. 294−297.
AND INDUSTRIAL ORGANIC CHEMISTRY
Antioxidant Properties of Some 5-Ethoxycarbonyl-Substituted
and Their Derivatives
A. V. Zamanova
, M. M. Kurbanova
, I. A. Rzaeva
, V. M. Farzaliev
, and M. A. Allakhverdiev
Kuliev Institute of Chemistry of Additives, National Academy of Sciences of Azerbaijan, Baku, Azerbaijan
Baku State University, Baku, Azerbaijan
Abstract—Inhibiting properties of some synthesized 5-ethoxycarbonyl-substituted 3,4-dihydropyrimidin-2(1H)-
ones (-thiones) and their derivatives in model reactions were studied.
It is known that 3,4-dihydropyrimidin-2(1Н)-ones
(-thiones) and their derivatives exhibit a wide spectrum
of biological activity. In addition, they are powerful
calcium channel blockers, antihypertensive drugs, and
neutopeptide antagonists .
In this study we examined the antioxidant properties of
some ethoxycarbonyl-substituted 3,4-dihydropyrimidin-
2(1H)-ones (-thiones) and their derivatives I–V. Com-
pounds I–III were synthesized by ternary condensation
dihydropyrimidine-5-carboxylate V was synthesized by
the reaction of 5-exthoxycarbonyl-6-methyl-4-phenyl-
3,4-dihydropyrimidin-2(1Н)-thione with epichlorohydrin
where Х = О, R = СН
(I); X = O, R = С
(II); Х =
S, R = С
1,2,3,4-tetrahydropyrimidine-5-carboxylate IV was
synthesized by the reaction of 5-exthoxycarbonyl-6-