Antioxidant, anticancer and electrochemical redox properties of new bis(2,3-dihydroquinazolin-4(1H)-one) derivatives

Antioxidant, anticancer and electrochemical redox properties of new... Electronic supplementary material The online version of this article (doi:10.1007/s11030-017-9748-5) contains supplementary material, which is available to authorized users. B Appaswami Lalitha lalitha2531@yahoo.co.in Department of Chemistry, Periyar University, Periyar Palkalai Nagar, Salem, Tamil Nadu 636 011, India 123 612 Mol Divers (2017) 21:611–620 Keywords Bis(2, 3-dihydroquinazolin-4(1H)-one) · However, only a few reports are available for the synthe- Antioxidant · DPPH radical scavenging activity · Anticancer · sis of bisquinazolinone [28–32] derivatives and, to the best Redox potential of our knowledge, this is the first report for the biolog- ical and electrochemical properties of these compounds. Considering this limited background, we planned the syn- Introduction thesis of new 3,3 -bis(dihydroquinazolin-4(1H )-one) and 2,2 -bis(dihydroquinazolin-4(1H )-one) derivatives to inves- In recent years, the exploration of novel synthetic compounds tigate their DPPH radical scavenging and electrochemical redox properties. with antioxidant properties has become an active area of research. Free radicals and oxygen derivatives are constantly generated in vivo by specific metabolic processes [1]. These radicals can easily react with most biological molecules Results and discussion including proteins, lipids, lipoproteins, DNA and damage them. The damage of cells caused by free radicals might Chemistry be responsible for the production of a wide range http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Molecular Diversity Springer Journals

Antioxidant, anticancer and electrochemical redox properties of new bis(2,3-dihydroquinazolin-4(1H)-one) derivatives

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Publisher
Springer International Publishing
Copyright
Copyright © 2017 by Springer International Publishing Switzerland
Subject
Life Sciences; Biochemistry, general; Organic Chemistry; Polymer Sciences; Pharmacy
ISSN
1381-1991
eISSN
1573-501X
D.O.I.
10.1007/s11030-017-9748-5
Publisher site
See Article on Publisher Site

Abstract

Electronic supplementary material The online version of this article (doi:10.1007/s11030-017-9748-5) contains supplementary material, which is available to authorized users. B Appaswami Lalitha lalitha2531@yahoo.co.in Department of Chemistry, Periyar University, Periyar Palkalai Nagar, Salem, Tamil Nadu 636 011, India 123 612 Mol Divers (2017) 21:611–620 Keywords Bis(2, 3-dihydroquinazolin-4(1H)-one) · However, only a few reports are available for the synthe- Antioxidant · DPPH radical scavenging activity · Anticancer · sis of bisquinazolinone [28–32] derivatives and, to the best Redox potential of our knowledge, this is the first report for the biolog- ical and electrochemical properties of these compounds. Considering this limited background, we planned the syn- Introduction thesis of new 3,3 -bis(dihydroquinazolin-4(1H )-one) and 2,2 -bis(dihydroquinazolin-4(1H )-one) derivatives to inves- In recent years, the exploration of novel synthetic compounds tigate their DPPH radical scavenging and electrochemical redox properties. with antioxidant properties has become an active area of research. Free radicals and oxygen derivatives are constantly generated in vivo by specific metabolic processes [1]. These radicals can easily react with most biological molecules Results and discussion including proteins, lipids, lipoproteins, DNA and damage them. The damage of cells caused by free radicals might Chemistry be responsible for the production of a wide range

Journal

Molecular DiversitySpringer Journals

Published: May 5, 2017

References

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