Antioxidant activity of 5,8-dihydroxy-1,4-dihydro-1,4-methanonaphthalene

Antioxidant activity of 5,8-dihydroxy-1,4-dihydro-1,4-methanonaphthalene 5,8-dihydroxy-1,4-dihydro-1,4-methanonaphthalene (DDMN), a substituted phenol, is synthesized by reduction of a cyclic dione, 1,4,4a,8a-tetrahydro-endo-1,4-methano-naphtha-5,8-dione (THMND). Pulse radiolysis technique has been employed to understand the nature of transient species formed on reaction of radiolytic species of water radiolysis with DDMN.•OH radicals were observed to react with DDMN with a bimolecular rate constant of 1.5×1010 dm3 mol−1 s−1. Inhibition of radiation induced lipid-peroxidation by DDMN was studied in rat liver microsomes by assessing the formation of thiobarbituric acid reactive substances (TBARS). It was found to be strongly inhibitory. The results suggest that DDMN has very good antioxidant activity and may possibly emerge as a good radio-protector. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Antioxidant activity of 5,8-dihydroxy-1,4-dihydro-1,4-methanonaphthalene

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Publisher
Springer Netherlands
Copyright
Copyright © 2008 by Springer
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/BF03039137
Publisher site
See Article on Publisher Site

Abstract

5,8-dihydroxy-1,4-dihydro-1,4-methanonaphthalene (DDMN), a substituted phenol, is synthesized by reduction of a cyclic dione, 1,4,4a,8a-tetrahydro-endo-1,4-methano-naphtha-5,8-dione (THMND). Pulse radiolysis technique has been employed to understand the nature of transient species formed on reaction of radiolytic species of water radiolysis with DDMN.•OH radicals were observed to react with DDMN with a bimolecular rate constant of 1.5×1010 dm3 mol−1 s−1. Inhibition of radiation induced lipid-peroxidation by DDMN was studied in rat liver microsomes by assessing the formation of thiobarbituric acid reactive substances (TBARS). It was found to be strongly inhibitory. The results suggest that DDMN has very good antioxidant activity and may possibly emerge as a good radio-protector.

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Apr 28, 2009

References

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