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Antineoplastics

Antineoplastics Reactions 1704, p37 - 2 Jun 2018 ★ S Pleural effusion due to histoplasmosis (first report for daunorubicin): case report A 23-year-old man developed pleural effusion due to histoplasmosis during treatment with daunorubicin, cyclophosphamide, vincristine and prednisolone for mixed- phenotype acute leukaemia. The man, who was hospitalised in Post Graduate Institute of Medical Education and Research in Chandigarh, India, was diagnosed with mixed-phenotype acute leukaemia. He was started on CHOP regimen, which consisted of daunorubicin, cyclophosphamide, vincristine and prednisolone [dosages and routes not stated]. He developed breathlessness and showed worsening of existing fatigue and fever following the second week of therapy. Therefore, he was rehospitalised. His chest radiograph showed right-sided moderate pleural effusion, without any gross parenchymal abnormality. Peripheral blood smears showed 42% blasts. Cytological testing of pleural fluid and blood cultures was initiated. The man was treated with vancomycin and cefoperazone/ sulbactam. His fever did not improve; therefore, amphotericin B liposomal therapy was added [liposomal amphotericin]. Therapeutic thoracentesis showed straw-colored exudative pleural fluid with pleural fluid protein to serum protein ratio of 0.89 and protein level of 3 g/L. Cytology testing was performed on 10mL haemorrhagic pleural fluid. The smears revealed many RBCs and blasts. The blasts were http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Antineoplastics

Reactions Weekly , Volume 1704 (1) – Jun 2, 2018
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Antineoplastics

Abstract

Reactions 1704, p37 - 2 Jun 2018 ★ S Pleural effusion due to histoplasmosis (first report for daunorubicin): case report A 23-year-old man developed pleural effusion due to histoplasmosis during treatment with daunorubicin, cyclophosphamide, vincristine and prednisolone for mixed- phenotype acute leukaemia. The man, who was hospitalised in Post Graduate Institute of Medical Education and Research in Chandigarh, India, was diagnosed with mixed-phenotype acute leukaemia. He was started on...
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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
DOI
10.1007/s40278-018-46680-4
Publisher site
See Article on Publisher Site

Abstract

Reactions 1704, p37 - 2 Jun 2018 ★ S Pleural effusion due to histoplasmosis (first report for daunorubicin): case report A 23-year-old man developed pleural effusion due to histoplasmosis during treatment with daunorubicin, cyclophosphamide, vincristine and prednisolone for mixed- phenotype acute leukaemia. The man, who was hospitalised in Post Graduate Institute of Medical Education and Research in Chandigarh, India, was diagnosed with mixed-phenotype acute leukaemia. He was started on CHOP regimen, which consisted of daunorubicin, cyclophosphamide, vincristine and prednisolone [dosages and routes not stated]. He developed breathlessness and showed worsening of existing fatigue and fever following the second week of therapy. Therefore, he was rehospitalised. His chest radiograph showed right-sided moderate pleural effusion, without any gross parenchymal abnormality. Peripheral blood smears showed 42% blasts. Cytological testing of pleural fluid and blood cultures was initiated. The man was treated with vancomycin and cefoperazone/ sulbactam. His fever did not improve; therefore, amphotericin B liposomal therapy was added [liposomal amphotericin]. Therapeutic thoracentesis showed straw-colored exudative pleural fluid with pleural fluid protein to serum protein ratio of 0.89 and protein level of 3 g/L. Cytology testing was performed on 10mL haemorrhagic pleural fluid. The smears revealed many RBCs and blasts. The blasts were

Journal

Reactions Weekly – Springer Journals

Published: Jun 2, 2018

References

  • Histoplasmosis in Pleural Effusion in a 23-Year-Old Man With Mixed-Phenotype Acute Leukemia.
    Sharma, S