Reactions 1704, p38 - 2 Jun 2018 Various toxicities and drug resistance leading to treatment failure: case report A 32-year-old woman developed hair loss, vomiting and neutropenia following treatment with etoposide, methotrexate, dactinomycin [Act-D], cyclophosphamide and vincristine for gestational trophoblastic neoplasia. Additionally, she developed resistance to methotrexate leading to treatment failure for gestational trophoblastic neoplasia [routes, durations of treatments to reactions onsets and outcomes not stated]. The woman (Gravida 2 para 0), who had metastatic gestational trophoblastic neoplasia, received single-agent chemotherapy with methotrexate. However, she developed resistance to methotrexate, leading to treatment failure. Hence multi-agent treatment (EMA-CO regimen) with etoposide, methotrexate, dactinomycin, cyclophosphamide and vincristine was started. Subsequently, she developed hair loss, vomiting and neutropenia. She received the EMA-CO regimen for a total duration of 5 months. Author comment: "[T]reatment with EMA-CO was generally well tolerated and toxicity was mild. In our case, there was no life-threatening toxicity, but hair loss, vomiting and neutropenia occurred. After suction evacuation, initially single agent chemotherapy using Methotrexate was done. However, this treatment failed. The patient with metastatic low risk GTN that developed resistance to single-agent chemotherapy achieved remission with combination chemotherapy." Han JS, et al. Coexisting complete hydatidiform mole and live foetus: A case report. Australasian Medical Journal 11: 227-230, No. 4, Jan 2018. Available from: URL: https://doi.org/10.21767/AMJ.2018.3379 - South Korea 803323079 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704
Reactions Weekly – Springer Journals
Published: Jun 2, 2018
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