Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Antineoplastics

Antineoplastics Reactions 1704, p35 - 2 Jun 2018 Depressed level of consciousness and renal disorders: 4 case reports In a prospective, multi-centre, observational study (EURO- B.O.S.S.) of 218 patients, four patients (including a female patient) [ages not stated; not all sexes stated] were described. One patient developed grade 4 depressed level of consciousness following treatment with ifosfamide, and another patient developed grade 4 renal toxicity while receiving doxorubicin, cisplatin and ifosfamide. The two remaining patients developed delayed methotrexate excretion associated with grade 3 nephrotoxicity or grade 1 creatinine elevation following the administration of methotrexate 8 g/m infusion [durations of treatments to reaction onsets not stated; not all routes, dosages and outcomes stated]. All patients were receiving the chemotherapies for primary high grade bone sarcoma. The female patient, who developed grade 4 renal toxicity, underwent dialysis and her renal function had normalised. Author comment: "The EURO-B.O.S.S. treatment concept led to results that seem comparable to those also achieved in younger patients with primary high-grade osteosarcoma, albeit at the cost of relevant side effects." Ferrari S, et al. EURO-B.O.S.S.: A European study on chemotherapy in bone- sarcoma patients aged over 40: Outcome in primary high-grade osteosarcoma. Tumori 104: 30-36, No. 1, Jan-Feb http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Antineoplastics

Reactions Weekly , Volume 1704 (1) – Jun 2, 2018
Download PDF
1 page

Antineoplastics

Abstract

Reactions 1704, p35 - 2 Jun 2018 Depressed level of consciousness and renal disorders: 4 case reports In a prospective, multi-centre, observational study (EURO- B.O.S.S.) of 218 patients, four patients (including a female patient) [ages not stated; not all sexes stated] were described. One patient developed grade 4 depressed level of consciousness following treatment with ifosfamide, and another patient developed grade 4 renal toxicity while receiving doxorubicin, cisplatin and ifosfamide....
Loading next page...
 
/lp/springer_journal/antineoplastics-McSxaIFqAB

References (1)

Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
DOI
10.1007/s40278-018-46678-5
Publisher site
See Article on Publisher Site

Abstract

Reactions 1704, p35 - 2 Jun 2018 Depressed level of consciousness and renal disorders: 4 case reports In a prospective, multi-centre, observational study (EURO- B.O.S.S.) of 218 patients, four patients (including a female patient) [ages not stated; not all sexes stated] were described. One patient developed grade 4 depressed level of consciousness following treatment with ifosfamide, and another patient developed grade 4 renal toxicity while receiving doxorubicin, cisplatin and ifosfamide. The two remaining patients developed delayed methotrexate excretion associated with grade 3 nephrotoxicity or grade 1 creatinine elevation following the administration of methotrexate 8 g/m infusion [durations of treatments to reaction onsets not stated; not all routes, dosages and outcomes stated]. All patients were receiving the chemotherapies for primary high grade bone sarcoma. The female patient, who developed grade 4 renal toxicity, underwent dialysis and her renal function had normalised. Author comment: "The EURO-B.O.S.S. treatment concept led to results that seem comparable to those also achieved in younger patients with primary high-grade osteosarcoma, albeit at the cost of relevant side effects." Ferrari S, et al. EURO-B.O.S.S.: A European study on chemotherapy in bone- sarcoma patients aged over 40: Outcome in primary high-grade osteosarcoma. Tumori 104: 30-36, No. 1, Jan-Feb

Journal

Reactions Weekly – Springer Journals

Published: Jun 2, 2018

There are no references for this article.