Antineoplastics

Antineoplastics Reactions 1704, p35 - 2 Jun 2018 Depressed level of consciousness and renal disorders: 4 case reports In a prospective, multi-centre, observational study (EURO- B.O.S.S.) of 218 patients, four patients (including a female patient) [ages not stated; not all sexes stated] were described. One patient developed grade 4 depressed level of consciousness following treatment with ifosfamide, and another patient developed grade 4 renal toxicity while receiving doxorubicin, cisplatin and ifosfamide. The two remaining patients developed delayed methotrexate excretion associated with grade 3 nephrotoxicity or grade 1 creatinine elevation following the administration of methotrexate 8 g/m infusion [durations of treatments to reaction onsets not stated; not all routes, dosages and outcomes stated]. All patients were receiving the chemotherapies for primary high grade bone sarcoma. The female patient, who developed grade 4 renal toxicity, underwent dialysis and her renal function had normalised. Author comment: "The EURO-B.O.S.S. treatment concept led to results that seem comparable to those also achieved in younger patients with primary high-grade osteosarcoma, albeit at the cost of relevant side effects." Ferrari S, et al. EURO-B.O.S.S.: A European study on chemotherapy in bone- sarcoma patients aged over 40: Outcome in primary high-grade osteosarcoma. Tumori 104: 30-36, No. 1, Jan-Feb 2018. Available from: URL: http:// doi.org/10.5301/tj.5000696 - Italy 803323787 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Antineoplastics

Reactions Weekly , Volume 1704 (1) – Jun 2, 2018
Free
1 page
Loading next page...
1 Page
 
/lp/springer_journal/antineoplastics-McSxaIFqAB
Publisher
Springer International Publishing
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
D.O.I.
10.1007/s40278-018-46678-5
Publisher site
See Article on Publisher Site

Abstract

Reactions 1704, p35 - 2 Jun 2018 Depressed level of consciousness and renal disorders: 4 case reports In a prospective, multi-centre, observational study (EURO- B.O.S.S.) of 218 patients, four patients (including a female patient) [ages not stated; not all sexes stated] were described. One patient developed grade 4 depressed level of consciousness following treatment with ifosfamide, and another patient developed grade 4 renal toxicity while receiving doxorubicin, cisplatin and ifosfamide. The two remaining patients developed delayed methotrexate excretion associated with grade 3 nephrotoxicity or grade 1 creatinine elevation following the administration of methotrexate 8 g/m infusion [durations of treatments to reaction onsets not stated; not all routes, dosages and outcomes stated]. All patients were receiving the chemotherapies for primary high grade bone sarcoma. The female patient, who developed grade 4 renal toxicity, underwent dialysis and her renal function had normalised. Author comment: "The EURO-B.O.S.S. treatment concept led to results that seem comparable to those also achieved in younger patients with primary high-grade osteosarcoma, albeit at the cost of relevant side effects." Ferrari S, et al. EURO-B.O.S.S.: A European study on chemotherapy in bone- sarcoma patients aged over 40: Outcome in primary high-grade osteosarcoma. Tumori 104: 30-36, No. 1, Jan-Feb 2018. Available from: URL: http:// doi.org/10.5301/tj.5000696 - Italy 803323787 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704

Journal

Reactions WeeklySpringer Journals

Published: Jun 2, 2018

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off