Antineoplastics Reactions 1680, p43 - 2 Dec 2017 Obstructive uropathy, unilateral hydronephrosis and renal damage: case report A 14-year-old boy developed obstructive uropathy, unilateral hydronephrosis and renal damage following chemotherapeutic treatment with daunorubicin, etoposide [vepezide], doxorubicin [adriamycin], prednisolone, vincristine, tioguanine, cytarabine and cyclophosphamide [dosages, routes and time to reactions onset not stated]. The boy presented for a periodical health test. During the ultrasonography, right hydronephrosis was revealed unexpectedly (he had no complaints). When he was 8 years old, he was diagnosed with acute myeloblastic leukaemia (AML). He was then treated with daunorubicin, etoposide, doxorubicin, prednisolone, vincristine, tioguanine, cytarabine and cyclophosphamide chemotherapy (AML-BFM-93 protocol). No renal lesions were found before and after chemotherapy. Previous yearly ultrasound examinations had showed no alteration of the kidneys. He was admitted for further treatment and tests. A repeat ultrasonography revealed right hydronephrosis. Anteroposterior diameter of pelvis was 50mm. Parenchymal thinning and calyceal dilatation were observed. Intravenous urography revealed normal left kidney. The boy underwent right retroperitoneoscopic nephrectomy. The kidney had slight atrophy of the parenchyma. Histopathology showed chronic tubulointerstitial nephritis. A copious infiltration of lymphocytes, several plasmocytes, and granulocytes was seen in the stroma. Tubular obstruction with a prominent amount of small eosinophilic and periodic acid-Schiff (PAS) positive cylinders was seen. Tubular epithelium was focally detached. Peritubular fibrosis was noted around excretory tubules. He was investigated for the possibility of BK virus nephritis, but no specific histological signs were seen. Author comment: "In the pathogenesis of this severe unilateral renal damage, we suspect the exacerbation of deleterious effects of cytostatic therapy on kidneys with intermittent hydronephrosis.""Renal damage as a consequence of haematologic malignancy and cytostatic therapy is well known". Simanauskiene E, et al. Unilateral hydronephrosis and renal damage after acute leukemia. Case Reports in Medicine 2012: 968491, 2012. Available from: URL: - Lithuania 803284780 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 Reactions Weekly Springer Journals


Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
1 page

Loading next page...
1 Page
Springer International Publishing
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
Publisher site
See Article on Publisher Site


You’re reading a free preview. Subscribe to read the entire article.

DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches


Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.



billed annually
Start Free Trial

14-day Free Trial