Reactions 1704, p39 - 2 Jun 2018 Various toxicities: case report A 9-month-old boy developed neutropenia, fungal infection, typhlitis and sepsis during induction chemotherapy with initial prednisolone followed by dexamethasone, daunorubicin, vincristine, asparaginase and cytarabine for B cell acute lymphoblastic leukaemia [routes, dosages, durations of treatments to reactions onsets and outcomes not stated]. The boy was diagnosed with B cell acute lymphoblastic leukaemia and found positive for hepatitis C virus genotype 3. Subsequently, he was started on induction chemotherapy consisting of initial eight days treatment with prednisolone followed by dexamethasone, daunorubicin, vincristine, asparaginase and cytarabine as per Children’s Oncology Group Infant Protocol. During induction therapy, he developed severe neutropenia, fungal infection, typhlitis and sepsis, and was admission to the paediatric ICU. The boy was treated with antifungals and broad-spectrum antibacterials. The paediatric gastroenterology team decided to continue chemotherapy, not actively treat hepatitis C and monitor clinical status and liver function tests. At the end of five induction therapy, a bone marrow examination showed morphological remission and minimal residual disease. Author comment: "In adults, simultaneous treatment of Hepatitis C with chemotherapy was avoided owing to greater therapy-associated toxicity". "During induction he developed severe neutropenia, sepsis, typhilitis and fungal infection". Ahmed QS, et al. Hepatitis C at presentation in a newly diagnosed infant with B Acute Lymphoblastic Leukemia. Pediatric Hematology Oncology Journal 3: 31-33, No. 1, Mar 2018. Available from: URL: http://doi.org/10.1016/j.phoj.2017.11.003 - Pakistan 803323976 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704
Reactions Weekly – Springer Journals
Published: Jun 2, 2018
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