Antimicrobial activity of new dumbbell-shaped phenothiazine cinnamides

Antimicrobial activity of new dumbbell-shaped phenothiazine cinnamides Herein, we report the synthesis and in vitro antibacterial and antifungal activities for twelve (E)-3-(10-(4-(10H-phenothiazin-10-yl)phenyl)-10H-phenothiazin-3-yl)-N-phenyl acrylamides (1–12). Structures of the compounds were established using IR, 1H NMR, mass and elemental analysis. These compounds exhibited promising activity against bacterials rather than fungal strains used. All the compounds inhibited the Gram-negative E. coli (ATCC 25922) and compounds 3, 5, 7, 8 and 12 also inhibited Gram-negative Pseudomonas (ATCC 27853) species in nano molar concentrations. Disc diffusion and micro-dilution (for MIC) methods were employed in estimating their in vitro antibacterial and antifungal activities. Ciprofloxacin and ketoconazole were used as the respective internal standards. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Antimicrobial activity of new dumbbell-shaped phenothiazine cinnamides

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Publisher
Springer Netherlands
Copyright
Copyright © 2016 by Springer Science+Business Media Dordrecht
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-016-2769-3
Publisher site
See Article on Publisher Site

Abstract

Herein, we report the synthesis and in vitro antibacterial and antifungal activities for twelve (E)-3-(10-(4-(10H-phenothiazin-10-yl)phenyl)-10H-phenothiazin-3-yl)-N-phenyl acrylamides (1–12). Structures of the compounds were established using IR, 1H NMR, mass and elemental analysis. These compounds exhibited promising activity against bacterials rather than fungal strains used. All the compounds inhibited the Gram-negative E. coli (ATCC 25922) and compounds 3, 5, 7, 8 and 12 also inhibited Gram-negative Pseudomonas (ATCC 27853) species in nano molar concentrations. Disc diffusion and micro-dilution (for MIC) methods were employed in estimating their in vitro antibacterial and antifungal activities. Ciprofloxacin and ketoconazole were used as the respective internal standards.

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Nov 2, 2016

References

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