Herein, we report the synthesis and in vitro antibacterial and antifungal activities for twelve (E)-3-(10-(4-(10H-phenothiazin-10-yl)phenyl)-10H-phenothiazin-3-yl)-N-phenyl acrylamides (1–12). Structures of the compounds were established using IR, 1H NMR, mass and elemental analysis. These compounds exhibited promising activity against bacterials rather than fungal strains used. All the compounds inhibited the Gram-negative E. coli (ATCC 25922) and compounds 3, 5, 7, 8 and 12 also inhibited Gram-negative Pseudomonas (ATCC 27853) species in nano molar concentrations. Disc diffusion and micro-dilution (for MIC) methods were employed in estimating their in vitro antibacterial and antifungal activities. Ciprofloxacin and ketoconazole were used as the respective internal standards.
Research on Chemical Intermediates – Springer Journals
Published: Nov 2, 2016
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