Curr Fungal Infect Rep (2017) 11:124–133 DOI 10.1007/s12281-017-0282-9 ADVANCES IN DIAGNOSIS OF INVASIVE FUNGAL INFECTIONS (S CHEN, SECTION EDITOR) Antifungal Susceptibility Testing of Candida and Cryptococcus Species and Mechanisms of Resistance: Implications for Clinical Laboratories 1 2 1,3 Catriona L. Halliday & Monica A. Slavin & Sharon C.-A. Chen Published online: 8 July 2017 Springer Science+Business Media, LLC 2017 Abstract technology is offering insights into the relationships between Purpose of Review Resistance to antifungal drugs amongst susceptibility results obtained by phenotypic and genotypic Candida species is a growing concern, and azole resistance methods. For Cryptococcus spp., CBPs are not established may be emerging in Cryptococcus species. This review pro- but species- and genetic type-specific EVCs are useful for vides a contemporary perspective, relevant to the clinical my- guiding therapy where clinically indicated. Isolates of geno- cology laboratory, of antifungal susceptibility testing of these type VGII appear to exhibit the highest MICs. fungi, focussing on the challenges of phenotypic and genotyp- Summary Antifungal susceptibility testing of yeasts is impor- ic methodologies to detect drug resistance. tant to detect drug resistance. For Candida spp., MICs have Recent Findings Standardised CLSI and EUCAST broth clinical utility for the azoles but detecting echinocandin
Current Fungal Infection Reports – Springer Journals
Published: Jul 8, 2017
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