Antidepressants/olanzapine/typical antipsychotics

Antidepressants/olanzapine/typical antipsychotics Reactions 1680, p36 - 2 Dec 2017 Antidepressants/olanzapine/typical antipsychotics Lipid derangement, weight gain and dyskinesia: case report A female patient [exact age not stated] developed lipid derangement, weight gain and dyskinesia following treatment with antidepressants, typical antipsychotics [specific drugs not stated] and olanzapine [routes and dosages not stated]. The female, who had a history of treatment resistant psychosis, presented to the hospital with hallucinations and suicidal ideations. During hospitalisation, psychosis persisted despite treatment with several antidepressants, olanzapine and typical antipsychotics. She also received inpatient milieu therapy. Her symptoms did not improve on the treatment. However, she developed lipid derangement, dyskinesia and weight gain, which were considered to be related to the drugs administered [time to reactions onset and outcomes not stated]. Olanzapine serum level was found to be supra therapeutic. Author comment: "Throughout hospitalization, patient continued to be psychotic in spite of treatment with several typical and atypical antipsychotics, antidepressants and inpatient milieu therapy. Interestingly, while her symptoms did not ameliorate in response to medications, she did develop side effects associated with the drugs given, including lipid derangement, weight gain and development of dyskinesia." Etwaroo NR, et al. Refractory psychosis in a patient with mega cisterna magna. CNS Spectrums 21: 115-116, No. 1, Feb 2016. Available from: URL: http:// [abstract] - USA 803284871 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 Reactions Weekly Springer Journals

Antidepressants/olanzapine/typical antipsychotics

Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
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Springer International Publishing
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
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