Reactions 1680, p35 - 2 Dec 2017
Antidepressants and L-methylfolate
Glycolimia (sweet food craving) and weight gain:
2 case reports
Two women [aged 57 and 52 years] developed glycolimia
(sugar craving), which led to weight gain during concomitant
administration of levomefolic-acid [L-methyl folate] with
venlafaxine or citalopram [not all routes and durations of
treatment to reaction onsets stated; outcomes not stated].
Case 1: A 57-year-old woman presented with generalised
anxiety disorder, major depression and burning mouth
syndrome and pedal oedema. She was undergoing treatment
with venlafaxine 100mg twice a day. Even after the treatment,
she continued to complain about her symptoms. Additionally,
she used to avoid sweets because she disliked them.
Thereafter, treatment with oral levomefolic-acid 15mg every
morning was started. Within a week, she developed craving for
chocolates and sweets. Later, after six months of treatment,
her depression abated but, glycolimia continued, and she
gained 30 lbs of weight.
Case 2: A 52-year-old woman with depression, presented
with complaints of anxiety, insomnia, impaired concentration,
trouble with memory and absence of sex drive. On
examination, pedal oedema was noted. At the time of
presentation, she was receiving oral citalopram 5mg every
morning. After presentation, she was started on levomefolic-
acid 5.6mg along with acetylcysteine [N-acetylcysteine] and
mecobalamin [methylcobalamin]. However, immediately after
initiation of levomefolic-acid therapy, she developed
glycolimia (craving for chocolates and sweets), and she gained
5 lbs weight in the following three months.
Author comment: "There are myriad possible mechanisms
for [levomefolic-acid]-induced glycolimia. [levomefolic-acid]
function of enhancing the efficacy of the antidepressants may
also enhance the side effects of these agents, including sweet
cravings and weight gain."
Hanif K, et al. L-methylfolate-induced glycolimia. CNS Spectrums 22: 79-80 abstr.
130, No. 1, Feb 2017. Available from: URL: http://doi.org/10.1017/
S1092852916000900 [abstract] - Netherlands Antilles
Reactions 2 Dec 2017 No. 16800114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved