Antidepressants and L-methylfolate interactions

Antidepressants and L-methylfolate interactions Reactions 1680, p35 - 2 Dec 2017 Antidepressants and L-methylfolate interactions Glycolimia (sweet food craving) and weight gain: 2 case reports Two women [aged 57 and 52 years] developed glycolimia (sugar craving), which led to weight gain during concomitant administration of levomefolic-acid [L-methyl folate] with venlafaxine or citalopram [not all routes and durations of treatment to reaction onsets stated; outcomes not stated]. Case 1: A 57-year-old woman presented with generalised anxiety disorder, major depression and burning mouth syndrome and pedal oedema. She was undergoing treatment with venlafaxine 100mg twice a day. Even after the treatment, she continued to complain about her symptoms. Additionally, she used to avoid sweets because she disliked them. Thereafter, treatment with oral levomefolic-acid 15mg every morning was started. Within a week, she developed craving for chocolates and sweets. Later, after six months of treatment, her depression abated but, glycolimia continued, and she gained 30 lbs of weight. Case 2: A 52-year-old woman with depression, presented with complaints of anxiety, insomnia, impaired concentration, trouble with memory and absence of sex drive. On examination, pedal oedema was noted. At the time of presentation, she was receiving oral citalopram 5mg every morning. After presentation, she was started on levomefolic- acid 5.6mg along with acetylcysteine [N-acetylcysteine] and mecobalamin [methylcobalamin]. However, immediately after initiation of levomefolic-acid therapy, she developed glycolimia (craving for chocolates and sweets), and she gained 5 lbs weight in the following three months. Author comment: "There are myriad possible mechanisms for [levomefolic-acid]-induced glycolimia. [levomefolic-acid] function of enhancing the efficacy of the antidepressants may also enhance the side effects of these agents, including sweet cravings and weight gain." Hanif K, et al. L-methylfolate-induced glycolimia. CNS Spectrums 22: 79-80 abstr. 130, No. 1, Feb 2017. Available from: URL: S1092852916000900 [abstract] - Netherlands Antilles 803284750 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 Reactions Weekly Springer Journals

Antidepressants and L-methylfolate interactions

Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
1 page

Loading next page...
1 Page
Springer International Publishing
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
Publisher site
See Article on Publisher Site

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.

DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches


Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.



billed annually
Start Free Trial

14-day Free Trial