Antidepressants and L-methylfolate interactions

Antidepressants and L-methylfolate interactions Reactions 1680, p35 - 2 Dec 2017 Antidepressants and L-methylfolate interactions Glycolimia (sweet food craving) and weight gain: 2 case reports Two women [aged 57 and 52 years] developed glycolimia (sugar craving), which led to weight gain during concomitant administration of levomefolic-acid [L-methyl folate] with venlafaxine or citalopram [not all routes and durations of treatment to reaction onsets stated; outcomes not stated]. Case 1: A 57-year-old woman presented with generalised anxiety disorder, major depression and burning mouth syndrome and pedal oedema. She was undergoing treatment with venlafaxine 100mg twice a day. Even after the treatment, she continued to complain about her symptoms. Additionally, she used to avoid sweets because she disliked them. Thereafter, treatment with oral levomefolic-acid 15mg every morning was started. Within a week, she developed craving for chocolates and sweets. Later, after six months of treatment, her depression abated but, glycolimia continued, and she gained 30 lbs of weight. Case 2: A 52-year-old woman with depression, presented with complaints of anxiety, insomnia, impaired concentration, trouble with memory and absence of sex drive. On examination, pedal oedema was noted. At the time of presentation, she was receiving oral citalopram 5mg every morning. After presentation, she was started on levomefolic- acid 5.6mg along with acetylcysteine [N-acetylcysteine] and mecobalamin [methylcobalamin]. However, immediately after initiation of levomefolic-acid therapy, she developed glycolimia (craving for chocolates and sweets), and she gained 5 lbs weight in the following three months. Author comment: "There are myriad possible mechanisms for [levomefolic-acid]-induced glycolimia. [levomefolic-acid] function of enhancing the efficacy of the antidepressants may also enhance the side effects of these agents, including sweet cravings and weight gain." Hanif K, et al. L-methylfolate-induced glycolimia. CNS Spectrums 22: 79-80 abstr. 130, No. 1, Feb 2017. Available from: URL: http://doi.org/10.1017/ S1092852916000900 [abstract] - Netherlands Antilles 803284750 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Antidepressants and L-methylfolate interactions

Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
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Publisher
Springer Journals
Copyright
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
D.O.I.
10.1007/s40278-017-38966-3
Publisher site
See Article on Publisher Site

Abstract

Reactions 1680, p35 - 2 Dec 2017 Antidepressants and L-methylfolate interactions Glycolimia (sweet food craving) and weight gain: 2 case reports Two women [aged 57 and 52 years] developed glycolimia (sugar craving), which led to weight gain during concomitant administration of levomefolic-acid [L-methyl folate] with venlafaxine or citalopram [not all routes and durations of treatment to reaction onsets stated; outcomes not stated]. Case 1: A 57-year-old woman presented with generalised anxiety disorder, major depression and burning mouth syndrome and pedal oedema. She was undergoing treatment with venlafaxine 100mg twice a day. Even after the treatment, she continued to complain about her symptoms. Additionally, she used to avoid sweets because she disliked them. Thereafter, treatment with oral levomefolic-acid 15mg every morning was started. Within a week, she developed craving for chocolates and sweets. Later, after six months of treatment, her depression abated but, glycolimia continued, and she gained 30 lbs of weight. Case 2: A 52-year-old woman with depression, presented with complaints of anxiety, insomnia, impaired concentration, trouble with memory and absence of sex drive. On examination, pedal oedema was noted. At the time of presentation, she was receiving oral citalopram 5mg every morning. After presentation, she was started on levomefolic- acid 5.6mg along with acetylcysteine [N-acetylcysteine] and mecobalamin [methylcobalamin]. However, immediately after initiation of levomefolic-acid therapy, she developed glycolimia (craving for chocolates and sweets), and she gained 5 lbs weight in the following three months. Author comment: "There are myriad possible mechanisms for [levomefolic-acid]-induced glycolimia. [levomefolic-acid] function of enhancing the efficacy of the antidepressants may also enhance the side effects of these agents, including sweet cravings and weight gain." Hanif K, et al. L-methylfolate-induced glycolimia. CNS Spectrums 22: 79-80 abstr. 130, No. 1, Feb 2017. Available from: URL: http://doi.org/10.1017/ S1092852916000900 [abstract] - Netherlands Antilles 803284750 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680

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Reactions WeeklySpringer Journals

Published: Dec 2, 2017

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