J Endocrinol Invest (2018) 41:455–463 https://doi.org/10.1007/s40618-017-0742-7 ORIGINAL ARTICLE Anti‑TNF‑α antibody alleviates insulin resistance in rats with sepsis‑induced stress hyperglycemia 1 1 1 2 1 W. Qu · C. Han · M. Li · J. Zhang · Z. Jiang Received: 3 May 2017 / Accepted: 7 August 2017 / Published online: 13 October 2017 © Italian Society of Endocrinology (SIE) 2017 Abstract IPGTT analysis revealed that blood glucose level was lower Purpose To explore the effects and mechanisms of anti- in the TNF group than that in the Cntl group (P < 0.05). tumor necrosis factor-α (TNF-α) antibody on insulin resist- The glucose infusion rate in the Cntl group was lower than ance (IR) in rats with sepsis-induced stress hyperglycemia. that in the Tnf and TNF groups (P < 0.05). The p-Akt/Akt, Methods The sepsis-induced stress hyperglycemic rat p-mTOR/mTOR ratio, and expression levels of NFκB, IKKβ model was constructed by cecal ligation and puncture and SOCS-3 were lower in the drug intervention than that in combined with the intraperitoneal injection of lipopolysac- the Cntl group (P < 0.05). charide. The rats were randomly divided into six groups: Conclusions Anti-TNF-α antibody could reduce IR by normal control (NC) group, surgical rats (Cntl) group, inhibiting AKt/mTOR signaling pathway and the expres- high-dose anti-TNF-α antibody
Journal of Endocrinological Investigation – Springer Journals
Published: Oct 13, 2017
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