Anti-oxidative action of ent-kaurene diterpenoids

Anti-oxidative action of ent-kaurene diterpenoids Nine ent-kaurene diterpenoids, leukamenin E, glaucocalyxin A, wangzaozi A, epinodisinol, epinodosin, rabdosin B, rabdosinate, lasiokaurin and oridonin, were separated from Isodon racemosa (Hemsl) Hara and Isodon japonica (Burm.f) Hara var. galaucocalyx (maxin). The protection against DNA damage induced by hydrogen peroxide in human peripheral blood mononuclear cells (PBMCs) and inhibition of lipid peroxidation in rat liver microsome were studied with comet assay and thiobarbituric acid reactive substances determination. All nine diterpenoids showed concentration-dependent protection in DNA damage in human PBMCs induced by 50 µM H2O2. The effects were similar and weaker than quercetin. The inhibitions of lipid peroxidation were obviously difference. Rabdosin B and oridonin were the strongest inhibitors, followed by lasiokaurin and wangzaozin A. Rabdosinate was the weakest and others were medium. The structure-activity relationship is discussed. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Anti-oxidative action of ent-kaurene diterpenoids

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Publisher
Springer Journals
Copyright
Copyright © 2006 by VSP
Subject
Chemistry; Inorganic Chemistry; Physical Chemistry; Catalysis
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1163/156856706778606543
Publisher site
See Article on Publisher Site

Abstract

Nine ent-kaurene diterpenoids, leukamenin E, glaucocalyxin A, wangzaozi A, epinodisinol, epinodosin, rabdosin B, rabdosinate, lasiokaurin and oridonin, were separated from Isodon racemosa (Hemsl) Hara and Isodon japonica (Burm.f) Hara var. galaucocalyx (maxin). The protection against DNA damage induced by hydrogen peroxide in human peripheral blood mononuclear cells (PBMCs) and inhibition of lipid peroxidation in rat liver microsome were studied with comet assay and thiobarbituric acid reactive substances determination. All nine diterpenoids showed concentration-dependent protection in DNA damage in human PBMCs induced by 50 µM H2O2. The effects were similar and weaker than quercetin. The inhibitions of lipid peroxidation were obviously difference. Rabdosin B and oridonin were the strongest inhibitors, followed by lasiokaurin and wangzaozin A. Rabdosinate was the weakest and others were medium. The structure-activity relationship is discussed.

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Jan 1, 2006

References

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