Pediatr Surg Int (2018) 34:307–313 DOI 10.1007/s00383-017-4201-5 ORIGINAL ARTICLE Anti-oxidants correct disturbance of redox enzymes in the hearts of rat fetuses with congenital diaphragmatic hernia 1 2 3 4 1,4 Rosa Aras-López · L. Almeida · V. Andreu-Fernández · J. Tovar · L. Martínez Accepted: 12 October 2017 / Published online: 27 October 2017 © Springer-Verlag GmbH Germany 2017 Abstract whereas those of SOD2, SOD3, catalase, and GPX1 mRNA Aim To evaluate if the redox system is unbalanced in the were decreased. Apocynin and EGCG treatments attenuated hearts of nitrofen-induced congenital diaphragmatic her- the increment of Nox and SOD activities and H O produc- 2 2 nia (CDH) animals and to study the possible preventive tion was only decreased by apocynin. effects of two anti-oxidant treatments, apocynin and epigal- Conclusion These findings suggest a possible preventive locatechin-3-gallate (EGCG). effect on the abnormal redox metabolism of anti-oxidant Methods Adult rats were divided into four groups. Group treatments in the hearts from rat fetuses with CDH. If the 1: rats received only vehicle on day E9.5. Group 2: rats same occurs in humans, it could represent a potential tool in received 100 mg nitrofen on day E9.5. Group 3: 1 month future prenatal treatment. before mating rats received apocynin 1.5 mM and, when
Pediatric Surgery International – Springer Journals
Published: Oct 27, 2017
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