Pediatr Surg Int (2018) 34:307–313 DOI 10.1007/s00383-017-4201-5 ORIGINAL ARTICLE Anti-oxidants correct disturbance of redox enzymes in the hearts of rat fetuses with congenital diaphragmatic hernia 1 2 3 4 1,4 Rosa Aras-López · L. Almeida · V. Andreu-Fernández · J. Tovar · L. Martínez Accepted: 12 October 2017 / Published online: 27 October 2017 © Springer-Verlag GmbH Germany 2017 Abstract whereas those of SOD2, SOD3, catalase, and GPX1 mRNA Aim To evaluate if the redox system is unbalanced in the were decreased. Apocynin and EGCG treatments attenuated hearts of nitrofen-induced congenital diaphragmatic her- the increment of Nox and SOD activities and H O produc- 2 2 nia (CDH) animals and to study the possible preventive tion was only decreased by apocynin. effects of two anti-oxidant treatments, apocynin and epigal- Conclusion These findings suggest a possible preventive locatechin-3-gallate (EGCG). effect on the abnormal redox metabolism of anti-oxidant Methods Adult rats were divided into four groups. Group treatments in the hearts from rat fetuses with CDH. If the 1: rats received only vehicle on day E9.5. Group 2: rats same occurs in humans, it could represent a potential tool in received 100 mg nitrofen on day E9.5. Group 3: 1 month future prenatal treatment. before mating rats received apocynin 1.5 mM and, when
Pediatric Surgery International – Springer Journals
Published: Oct 27, 2017
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera