J Mater Sci: Mater Med (2017) 28:136 DOI 10.1007/s10856-017-5931-6 TISSUE ENGINEERING CONSTRUCTS AND CELL SUBSTRATES Original Research Anti-ﬁbronectin aptamers improve the colonization of chitosan ﬁlms modiﬁed with D-(+) Rafﬁnose by murine osteoblastic cells 1,2 1,2,3 4 3 4 2 ● ● ● ● ● ● L. Parisi C. Galli A. Bianchera P. Lagonegro L. Elviri A. Smerieri 1,2 1,2 4 1,2,3 ● ● ● S. Lumetti E. Manfredi R. Bettini G. M. Macaluso Received: 12 January 2017 / Accepted: 20 June 2017 / Published online: 31 July 2017 © Springer Science+Business Media, LLC 2017 Abstract The aim of the present study was to investigate amount of adsorbed ﬁbronectin, but affected osteoblasts how the enrichment of chitosan ﬁlms with anti-ﬁbronectin behavior. Cell growth was proportional to the amount of aptamers could enhance scaffold colonization by osteo- aptamer used for the functionalization, as well as aptamers blasts, by improving their adhesion and accelerating their inﬂuenced cell morphology and their adhesion to the sub- proliferation. Chitosan discs were enriched with excess of strate. Our results demonstrate that the enrichment of chit- anti-ﬁbronectin aptamer. Aptamer adsorption on chitosan osan ﬁlms with aptamers could selectively improve was monitored by measuring aptamer concentration in the
Journal of Materials Science: Materials in Medicine – Springer Journals
Published: Jul 31, 2017
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