Anti-cell growth and anti-cancer stem cell activities of the non-canonical hedgehog inhibitor GANT61 in triple-negative breast cancer cells

Anti-cell growth and anti-cancer stem cell activities of the non-canonical hedgehog inhibitor... Breast Cancer (2017) 24:683–693 DOI 10.1007/s12282-017-0757-0 ORIGINAL ARTICLE Anti-cell growth and anti-cancer stem cell activities of the non-canonical hedgehog inhibitor GANT61 in triple-negative breast cancer cells 1 1 1 1 • • • • Yoshikazu Koike Yusuke Ohta Wataru Saitoh Tetsumasa Yamashita 2 2 1 • • Naoki Kanomata Takuya Moriya Junichi Kurebayashi Received: 23 September 2016 / Accepted: 23 January 2017 / Published online: 31 January 2017 The Japanese Breast Cancer Society 2017 Abstract and increased apoptosis. GANT61 significantly decreased Background Triple-negative breast cancer (TNBC) exhi- the CSC proportion in all TNBC cell lines. Paclitaxel bits biologically aggressive behavior and has a poor decreased cell growth, but not the CSC proportion. Com- prognosis. Novel molecular targeting agents are needed to bined treatments of GANT61 and paclitaxel more than control TNBC. Recent studies revealed that the non- additively enhanced anti-cell growth and/or anti-CSC canonical hedgehog (Hh) signaling pathway plays impor- activities. tant roles in the regulation of cancer stem cells (CSCs) in Conclusions The non-canonical Hh inhibitor GANT61 breast cancer. Therefore, the anti-cell growth and anti-CSC decreased not only cell growth, but also the CSC popula- effects of the non-canonical Hh inhibitor GANT61 were tion in TNBC cells. GANT61 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Breast Cancer Springer Journals

Anti-cell growth and anti-cancer stem cell activities of the non-canonical hedgehog inhibitor GANT61 in triple-negative breast cancer cells

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Publisher
Springer Japan
Copyright
Copyright © 2017 by The Japanese Breast Cancer Society
Subject
Medicine & Public Health; Surgical Oncology; Oncology; Surgery; Cancer Research
ISSN
1340-6868
eISSN
1880-4233
D.O.I.
10.1007/s12282-017-0757-0
Publisher site
See Article on Publisher Site

Abstract

Breast Cancer (2017) 24:683–693 DOI 10.1007/s12282-017-0757-0 ORIGINAL ARTICLE Anti-cell growth and anti-cancer stem cell activities of the non-canonical hedgehog inhibitor GANT61 in triple-negative breast cancer cells 1 1 1 1 • • • • Yoshikazu Koike Yusuke Ohta Wataru Saitoh Tetsumasa Yamashita 2 2 1 • • Naoki Kanomata Takuya Moriya Junichi Kurebayashi Received: 23 September 2016 / Accepted: 23 January 2017 / Published online: 31 January 2017 The Japanese Breast Cancer Society 2017 Abstract and increased apoptosis. GANT61 significantly decreased Background Triple-negative breast cancer (TNBC) exhi- the CSC proportion in all TNBC cell lines. Paclitaxel bits biologically aggressive behavior and has a poor decreased cell growth, but not the CSC proportion. Com- prognosis. Novel molecular targeting agents are needed to bined treatments of GANT61 and paclitaxel more than control TNBC. Recent studies revealed that the non- additively enhanced anti-cell growth and/or anti-CSC canonical hedgehog (Hh) signaling pathway plays impor- activities. tant roles in the regulation of cancer stem cells (CSCs) in Conclusions The non-canonical Hh inhibitor GANT61 breast cancer. Therefore, the anti-cell growth and anti-CSC decreased not only cell growth, but also the CSC popula- effects of the non-canonical Hh inhibitor GANT61 were tion in TNBC cells. GANT61

Journal

Breast CancerSpringer Journals

Published: Jan 31, 2017

References

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