Anti-CD8 treatment alters interleukin-4 but not interferon-γ mRNA levels in murine sensory ganglia during herpes simplex virus infection

Anti-CD8 treatment alters interleukin-4 but not interferon-γ mRNA levels in murine sensory... Clearance of herpes simplex virus (HSV) from sensory ganglia of infected mice is dependent on CD8 + cells but not on the death of infected neurons. The mechanism of action of CD8 + cells in HSV infected ganglia is therefore unknown. The determine which cytokines might be involved in the CD8 + cell dependent response to ganglionic HSV infection, IL-2, IL-4, IL-6, IL-10, and IFN-γ mRNA levels were measured in infected ganglia from immunocompetent and anti-CD8 treated mice. Anti-CD8 treatment increased the abundance of mRNA encoding IL-4, and, to a lesser extent, IL-2, and IL-6. Significantly, IFN-γ mRNA was not affected. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Anti-CD8 treatment alters interleukin-4 but not interferon-γ mRNA levels in murine sensory ganglia during herpes simplex virus infection

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Publisher
Springer Journals
Copyright
Copyright © Wien by 1999 Springer-Verlag/
Subject
Legacy
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s007050050637
Publisher site
See Article on Publisher Site

Abstract

Clearance of herpes simplex virus (HSV) from sensory ganglia of infected mice is dependent on CD8 + cells but not on the death of infected neurons. The mechanism of action of CD8 + cells in HSV infected ganglia is therefore unknown. The determine which cytokines might be involved in the CD8 + cell dependent response to ganglionic HSV infection, IL-2, IL-4, IL-6, IL-10, and IFN-γ mRNA levels were measured in infected ganglia from immunocompetent and anti-CD8 treated mice. Anti-CD8 treatment increased the abundance of mRNA encoding IL-4, and, to a lesser extent, IL-2, and IL-6. Significantly, IFN-γ mRNA was not affected.

Journal

Archives of VirologySpringer Journals

Published: Nov 1, 1999

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