Clearance of herpes simplex virus (HSV) from sensory ganglia of infected mice is dependent on CD8 + cells but not on the death of infected neurons. The mechanism of action of CD8 + cells in HSV infected ganglia is therefore unknown. The determine which cytokines might be involved in the CD8 + cell dependent response to ganglionic HSV infection, IL-2, IL-4, IL-6, IL-10, and IFN-γ mRNA levels were measured in infected ganglia from immunocompetent and anti-CD8 treated mice. Anti-CD8 treatment increased the abundance of mRNA encoding IL-4, and, to a lesser extent, IL-2, and IL-6. Significantly, IFN-γ mRNA was not affected.
Archives of Virology – Springer Journals
Published: Nov 1, 1999
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