research highlights SYSTEMS BIOLOGY Nature 553, 342–346 (2018) The authors tested all pairwise interactions for 200 Arabidopsis LRR extracellular domains to build an almost complete map. They validated the robustness and biological relevance of these interactions through various approaches, including genetics. New receptors acting in immunity and growth were discovered, and receptors with small LRR domains were found to be quite promiscuous. Genetically removing one of these central nodes indirectly disrupted biological responses Credit: Getty Images/Istockphoto/ controlled by other receptors, showing Thinkstock/Pkujiahe that the network’s overall stability is important. Each plant cell contains hundreds of plasma We used to think of membrane receptors membrane receptors that are constantly on as isolated entities, at most interacting with the lookout for environmentally produced or one co-receptor, each starting an isolated endogenous signals. Members of the largest downstream signalling pathway. This work receptor subfamily display extracellular not only identifies new candidates to explore leucine-rich repeats (LRRs) as their sensing individually, but exposes a much more antenna and an intracellular kinase domain complex view of an interconnected grid of as their signalling switch, creating molecular receptors influencing each other bridges between the outside and inside of to correctly integrate and process the cell. We know a few examples of these extracellular information. receptor kinases binding to each other through the LRR domain, forming active Guillaume Tena heterodimer complexes. Youssef Belkhadir and colleagues have now mapped the full Published online: 29 January 2018 https://doi.org/10.1038/s41477-018-0111-3 interaction network. NATurE PLANTS | VOL 4 | FEBRUARY 2018 | 61 | www.nature.com/natureplants © 2018 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. © 2018 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.
Nature Plants – Springer Journals
Published: Jan 29, 2018
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