Antenna network

Antenna network research highlights SYSTEMS BIOLOGY Nature 553, 342–346 (2018) The authors tested all pairwise interactions for 200 Arabidopsis LRR extracellular domains to build an almost complete map. They validated the robustness and biological relevance of these interactions through various approaches, including genetics. New receptors acting in immunity and growth were discovered, and receptors with small LRR domains were found to be quite promiscuous. Genetically removing one of these central nodes indirectly disrupted biological responses Credit: Getty Images/Istockphoto/ controlled by other receptors, showing Thinkstock/Pkujiahe that the network’s overall stability is important. Each plant cell contains hundreds of plasma We used to think of membrane receptors membrane receptors that are constantly on as isolated entities, at most interacting with the lookout for environmentally produced or one co-receptor, each starting an isolated endogenous signals. Members of the largest downstream signalling pathway. This work receptor subfamily display extracellular not only identifies new candidates to explore leucine-rich repeats (LRRs) as their sensing individually, but exposes a much more antenna and an intracellular kinase domain complex view of an interconnected grid of as their signalling switch, creating molecular receptors influencing each other bridges between the outside and inside of to correctly integrate and process the cell. We know a few examples of these extracellular information. receptor kinases binding to each other through the LRR domain, forming active Guillaume Tena heterodimer complexes. Youssef Belkhadir and colleagues have now mapped the full Published online: 29 January 2018 https://doi.org/10.1038/s41477-018-0111-3 interaction network. NATurE PLANTS | VOL 4 | FEBRUARY 2018 | 61 | www.nature.com/natureplants © 2018 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. © 2018 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Plants Springer Journals

Antenna network

Free
1 page
Loading next page...
1 Page
 
/lp/springer_journal/antenna-network-8vsjr1jJeV
Publisher
Nature Publishing Group UK
Copyright
Copyright © 2018 by The Author(s)
Subject
Life Sciences; Life Sciences, general; Plant Sciences
eISSN
2055-0278
D.O.I.
10.1038/s41477-018-0111-3
Publisher site
See Article on Publisher Site

Abstract

research highlights SYSTEMS BIOLOGY Nature 553, 342–346 (2018) The authors tested all pairwise interactions for 200 Arabidopsis LRR extracellular domains to build an almost complete map. They validated the robustness and biological relevance of these interactions through various approaches, including genetics. New receptors acting in immunity and growth were discovered, and receptors with small LRR domains were found to be quite promiscuous. Genetically removing one of these central nodes indirectly disrupted biological responses Credit: Getty Images/Istockphoto/ controlled by other receptors, showing Thinkstock/Pkujiahe that the network’s overall stability is important. Each plant cell contains hundreds of plasma We used to think of membrane receptors membrane receptors that are constantly on as isolated entities, at most interacting with the lookout for environmentally produced or one co-receptor, each starting an isolated endogenous signals. Members of the largest downstream signalling pathway. This work receptor subfamily display extracellular not only identifies new candidates to explore leucine-rich repeats (LRRs) as their sensing individually, but exposes a much more antenna and an intracellular kinase domain complex view of an interconnected grid of as their signalling switch, creating molecular receptors influencing each other bridges between the outside and inside of to correctly integrate and process the cell. We know a few examples of these extracellular information. receptor kinases binding to each other through the LRR domain, forming active Guillaume Tena heterodimer complexes. Youssef Belkhadir and colleagues have now mapped the full Published online: 29 January 2018 https://doi.org/10.1038/s41477-018-0111-3 interaction network. NATurE PLANTS | VOL 4 | FEBRUARY 2018 | 61 | www.nature.com/natureplants © 2018 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. © 2018 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.

Journal

Nature PlantsSpringer Journals

Published: Jan 29, 2018

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off