Incorporating Mouse Genome Mammalian Genome 11, 1040 (2000). © Springer-Verlag New York Inc. 2000 DOI: 10.1007/s003350010229 Call for Applications: Mouse Genotyping at the Center for In- Opportunity for Obtaining the Sequence of Mouse DNA of herited Disease Research (CIDR) (www.cidr.jhmi.edu <http:// Particularly High Biomedical Interest. Next Receipt Date: De- www.cidr.jhmi.edu> cember, 2000. The Center for Inherited Disease Research (CIDR) is an NIH- As part of the NIH Mouse Genome Sequencing Network’s effort supported resource providing high throughput genotyping services to determine the complete DNA sequence of the laboratory mouse, to research efforts that are attempting to identify genetic loci and strain C57BL/6J, the National Human Genome Research Insti- allelic variants involved in human disease. Beginning with the July tute (NHGRI), has initiated a program that will allow investiga- 1, 2000 application submission deadline, the Center will offer tors to obtain the sequence of specific regions of the mouse ge- genotyping services to investigators conducting mapping studies nome. While the initial emphasis of the Network will be on pro- with inbred strains of mice. Using DNA samples provided by the ducing a working draft sequence of the entire mouse genome, principal investigator, CIDR will carry out genome-wide scans some of the available sequencing capacity will be devoted to par- using automated fluorescent technology to genotype microsatellite ticular regions which have special significance for advancing bio- markers. All data will remain the property of the principal inves- medical research. Any investigator interested in obtaining the tigator and will be returned once the studies at CIDR are complete. sequence of a specific region of the mouse genome which has A total of 47 inbred strains have been typed. A list of the strains, been identified in the RPCI 23 BAC library may submit a short, along with allele sizes for ~ 300 markers, is available on the CIDR Web-based request describing the region, its importance, and its web site. Only mouse mapping projects requesting whole genome readiness to be sequenced. A panel of peer reviewers will con- scans totaling at least 10,000 genotypes (DNA sample × micro- sider the requests and advise the NHGRI on the priority of the satellite marker) will be accepted. regions requested. Those judged to be sufficiently important to CIDR is a joint effort by eleven participating institutes at NIH: warrant priority sequencing will be listed for the centers engaged the National Cancer Institute (NCI), the National Eye Institute in mouse genomic sequencing to choose and sequence, up to the (NEI), the National Human Genome Research Institute (NHGRI), maximum capacity available for this activity. There will be no cost the National Institute on Aging (NIA), the National Institute of to investigators seeking this sequencing service; the sequencing Child Health and Human Development (NICHD), the National will be done by centers that have already been funded through the Institute of Dental and Craniofacial Research (NIDCR), the Na- Network. However, as with all sequence data generated by the tional Institute on Deafness and Other Communication Disorders Human Genome Project, unfinished data will be submitted to Gen- (NIDCD), the National Institute on Drug Abuse (NIDA), the Na- Bank within 24 hours of generation of 2kb assemblies, and fin- tional Institute of Environmental Health Services (NIEHS), the ished data as soon as completed. No sequence data will be made National Institute of Mental Health (NIMH), and the National available to the requestor prior to public release. All publications Institute of Neurological Disorders and Stroke (NINDS). CIDR is using this data must acknowledge the publicly funded sequencing located at the Bayview Research Campus of the Johns Hopkins effort. University and is operated by the University through a contract For a more complete description of the program and to access from the NIH. the request form, please visit our website: http://www.nih.gov/ Investigators whose mapping projects are supported by one of science/models/mouse/mouseseq/index.html. the eleven NIH Institutes participating in CIDR will receive free Submission Dates for 2000: February 1, April 1, June 1, August genotyping. Other investigators are eligible to use CIDR on a fee 1, October 1, December 1. for service basis. To discuss programmatic issues contact: Bettie J. Graham, Access to CIDR is open to all investigators on a competitive Ph.D., National Institutes of Health, Bethesda, MD 20892-2033. basis through peer review. For a more complete description of Email: firstname.lastname@example.org; TEL: (301) 496-7531. CIDR, including specific application procedures, visit our Website To discuss review issues contact: Jerry Roberts, Ph.D., National at http://www.cidr.jhmi.edu/ <http://www.cidr.jhmi.edu/>. If you Institutes of Health, Bethesda, MD 20892-2032. E-mail: would like additional information, contact Dr. Jerry Roberts, Sci- email@example.com; TEL: (301) 402-0838. entific Review Administrator and Executive Director, CIDR Board of Governors, in the NHGRI Office of Scientific Review. Application Deadlines: March 1, July 1, November 1.
Mammalian Genome – Springer Journals
Published: Nov 1, 2000
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