Angiotensin-(1–7) and Alamandine on Experimental Models of Hypertension and Atherosclerosis

Angiotensin-(1–7) and Alamandine on Experimental Models of Hypertension and Atherosclerosis Purpose of Review The purpose of this review was to summarize the current knowledge on the role of angiotensin-(1–7) [Ang-(1–7)] and alamandine in experimental hypertension and atherosclerosis. Recent Findings The renin-angiotensin system (RAS) is a very complex system, composed of a cascade of enzymes, peptides, and receptors, known to be involved in the pathogenesis of hypertension and atherosclerosis. Ang-(1–7), identified and charac- terized in 1987, and alamandine, discovered 16 years after, are the newest two main effector molecules from the RAS, protecting the vascular system against hypertension and atherosclerosis. Summary While the beneficial effects of Ang-(1–7) have been widely studied in several experimental models of hypertension, much less studies were performed in experimental models of atherosclerosis. Alamandine has shown similar vascular effects to Ang-(1–7), namely, endothelial-dependent vasorelaxation mediated by nitric oxide and hypotensive effects in experimental hypertension. There are few studies on the effects of alamandine on atherosclerosis. . . . . . Keywords Renin-angiotensin system Angiotensin-(1–7) Mas receptor Alamandine MrgD receptor; hypertension Atherosclerosis Introduction muscle cell (VSMC) phenotype, presence of vascular inflam- mation and oxidative stress, and activation of the renin- There is a global epidemia of cardiovascular disease (CVD). angiotensin system (RAS) [2, 3]. The number of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Hypertension Reports Springer Journals

Angiotensin-(1–7) and Alamandine on Experimental Models of Hypertension and Atherosclerosis

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Publisher
Springer US
Copyright
Copyright © 2018 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Medicine & Public Health; Internal Medicine; Cardiology; Metabolic Diseases; Nephrology; Primary Care Medicine; General Practice / Family Medicine
ISSN
1522-6417
eISSN
1534-3111
D.O.I.
10.1007/s11906-018-0798-6
Publisher site
See Article on Publisher Site

Abstract

Purpose of Review The purpose of this review was to summarize the current knowledge on the role of angiotensin-(1–7) [Ang-(1–7)] and alamandine in experimental hypertension and atherosclerosis. Recent Findings The renin-angiotensin system (RAS) is a very complex system, composed of a cascade of enzymes, peptides, and receptors, known to be involved in the pathogenesis of hypertension and atherosclerosis. Ang-(1–7), identified and charac- terized in 1987, and alamandine, discovered 16 years after, are the newest two main effector molecules from the RAS, protecting the vascular system against hypertension and atherosclerosis. Summary While the beneficial effects of Ang-(1–7) have been widely studied in several experimental models of hypertension, much less studies were performed in experimental models of atherosclerosis. Alamandine has shown similar vascular effects to Ang-(1–7), namely, endothelial-dependent vasorelaxation mediated by nitric oxide and hypotensive effects in experimental hypertension. There are few studies on the effects of alamandine on atherosclerosis. . . . . . Keywords Renin-angiotensin system Angiotensin-(1–7) Mas receptor Alamandine MrgD receptor; hypertension Atherosclerosis Introduction muscle cell (VSMC) phenotype, presence of vascular inflam- mation and oxidative stress, and activation of the renin- There is a global epidemia of cardiovascular disease (CVD). angiotensin system (RAS) [2, 3]. The number of

Journal

Current Hypertension ReportsSpringer Journals

Published: Mar 14, 2018

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