Angiotensin-(1–7) and Alamandine on Experimental Models of Hypertension and Atherosclerosis

Angiotensin-(1–7) and Alamandine on Experimental Models of Hypertension and Atherosclerosis Purpose of Review The purpose of this review was to summarize the current knowledge on the role of angiotensin-(1–7) [Ang-(1–7)] and alamandine in experimental hypertension and atherosclerosis. Recent Findings The renin-angiotensin system (RAS) is a very complex system, composed of a cascade of enzymes, peptides, and receptors, known to be involved in the pathogenesis of hypertension and atherosclerosis. Ang-(1–7), identified and charac- terized in 1987, and alamandine, discovered 16 years after, are the newest two main effector molecules from the RAS, protecting the vascular system against hypertension and atherosclerosis. Summary While the beneficial effects of Ang-(1–7) have been widely studied in several experimental models of hypertension, much less studies were performed in experimental models of atherosclerosis. Alamandine has shown similar vascular effects to Ang-(1–7), namely, endothelial-dependent vasorelaxation mediated by nitric oxide and hypotensive effects in experimental hypertension. There are few studies on the effects of alamandine on atherosclerosis. . . . . . Keywords Renin-angiotensin system Angiotensin-(1–7) Mas receptor Alamandine MrgD receptor; hypertension Atherosclerosis Introduction muscle cell (VSMC) phenotype, presence of vascular inflam- mation and oxidative stress, and activation of the renin- There is a global epidemia of cardiovascular disease (CVD). angiotensin system (RAS) [2, 3]. The number of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Hypertension Reports Springer Journals

Angiotensin-(1–7) and Alamandine on Experimental Models of Hypertension and Atherosclerosis

Loading next page...
 
/lp/springer_journal/angiotensin-1-7-and-alamandine-on-experimental-models-of-hypertension-i7bk0Bnk08
Publisher
Springer US
Copyright
Copyright © 2018 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Medicine & Public Health; Internal Medicine; Cardiology; Metabolic Diseases; Nephrology; Primary Care Medicine; General Practice / Family Medicine
ISSN
1522-6417
eISSN
1534-3111
D.O.I.
10.1007/s11906-018-0798-6
Publisher site
See Article on Publisher Site

Abstract

Purpose of Review The purpose of this review was to summarize the current knowledge on the role of angiotensin-(1–7) [Ang-(1–7)] and alamandine in experimental hypertension and atherosclerosis. Recent Findings The renin-angiotensin system (RAS) is a very complex system, composed of a cascade of enzymes, peptides, and receptors, known to be involved in the pathogenesis of hypertension and atherosclerosis. Ang-(1–7), identified and charac- terized in 1987, and alamandine, discovered 16 years after, are the newest two main effector molecules from the RAS, protecting the vascular system against hypertension and atherosclerosis. Summary While the beneficial effects of Ang-(1–7) have been widely studied in several experimental models of hypertension, much less studies were performed in experimental models of atherosclerosis. Alamandine has shown similar vascular effects to Ang-(1–7), namely, endothelial-dependent vasorelaxation mediated by nitric oxide and hypotensive effects in experimental hypertension. There are few studies on the effects of alamandine on atherosclerosis. . . . . . Keywords Renin-angiotensin system Angiotensin-(1–7) Mas receptor Alamandine MrgD receptor; hypertension Atherosclerosis Introduction muscle cell (VSMC) phenotype, presence of vascular inflam- mation and oxidative stress, and activation of the renin- There is a global epidemia of cardiovascular disease (CVD). angiotensin system (RAS) [2, 3]. The number of

Journal

Current Hypertension ReportsSpringer Journals

Published: Mar 14, 2018

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off