J Endocrinol Invest (2018) 41:383–388 https://doi.org/10.1007/s40618-017-0762-3 REVIEW Androgen excess and metabolic disorders in women with PCOS: beyond the body mass index 1 1 1 1 R. A. Condorelli · A. E. Calogero · M. Di Mauro · L. M. Mongioi’ · 1 1 1 R. Cannarella · G. Rosta · S. La Vignera Received: 27 June 2017 / Accepted: 13 September 2017 / Published online: 23 September 2017 © Italian Society of Endocrinology (SIE) 2017 Abstract Keywords PCOS · Insulin resistance · Obesity · Background Insulin resistance is a common feature among Hyperandrogenism women with polycystic ovary syndrome (PCOS), especially in those patients with hyperandrogenism and chronic ano- Abbreviations vulation. PCOS women are at risk for developing metabolic A Androstenedione syndrome, impaired glucose tolerance and type II diabetes AACE American Association of Clinical mellitus (DM II). Endocrinology Objective The aim of this review is to explore the exist- ACE American College of Endocrinology ing knowledge of the interplay between androgen excess, BMI Body mass index pancreatic β-cell function, non-alcoholic fatty liver disease DHEAS Dehydroepiandrosterone sulfate (NAFLD), intra-abdominal and subcutaneous (SC) abdomi-DHT Di-hydro-testosterone nal adipocytes in PCOS, providing a better comprehension DM II Type II diabetes mellitus of the molecular mechanisms of diabetologic interest. DNMT3 De novo methyl-transferase 3 Methods A comprehensive ME DLINE search was per- FFA Free
Journal of Endocrinological Investigation – Springer Journals
Published: Sep 23, 2017
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