Access the full text.
Sign up today, get DeepDyve free for 14 days.
G. Dimitriadis, I. Kyrou, H. Randeva (2016)
Polycystic Ovary Syndrome as a Proinflammatory State: The Role of Adipokines.Current pharmaceutical design, 22 36
P Moghetti (1996)
952JCEM, 81
S. Malin, J. Kirwan, Chang Sia, F. González (2015)
Pancreatic β-cell dysfunction in polycystic ovary syndrome: role of hyperglycemia-induced nuclear factor-κB activation and systemic inflammation.American journal of physiology. Endocrinology and metabolism, 308 9
K. Petersen, S. Dufour, D. Savage, S. Bilz, Jerry Solomon, S. Yonemitsu, G. Cline, D. Befroy, L. Zemany, B. Kahn, X. Papademetris, D. Rothman, G. Shulman (2007)
Inaugural Article: The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndromeProceedings of the National Academy of Sciences of the United States of America
KF Petersen, S Dufour, DB Savage, S Bilz, G Solomon, S Yonemitsu (2007)
The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndromeProc Natl Acad Sci USA, 104
S. Cassar, M. Misso, W. Hopkins, C. Shaw, H. Teede, N. Stepto (2016)
Insulin resistance in polycystic ovary syndrome: a systematic review and meta-analysis of euglycaemic-hyperinsulinaemic clamp studies.Human reproduction, 31 11
N. Goodman, R. Cobin, W. Futterweit, J. Glueck, R. Legro, E. Carmina (2015)
AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS, AMERICAN COLLEGE OF ENDOCRINOLOGY, AND ANDROGEN EXCESS AND PCOS SOCIETY DISEASE STATE CLINICAL REVIEW: GUIDE TO THE BEST PRACTICES IN THE EVALUATION AND TREATMENT OF POLYCYSTIC OVARY SYNDROME - PART 2.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, 21 12
F. Jornayvaz, V. Samuel, G. Shulman (2010)
The role of muscle insulin resistance in the pathogenesis of atherogenic dyslipidemia and nonalcoholic fatty liver disease associated with the metabolic syndrome.Annual review of nutrition, 30
E. Makri, K. Tziomalos (2016)
Prevalence, etiology and management of non-alcoholic fatty liver disease in patients with polycystic ovary syndrome.Minerva endocrinologica, 42 2
Trang Le, J. Nestler, J. Strauss, Edmond Wickham (2012)
Sex hormone-binding globulin and type 2 diabetes mellitusTrends in Endocrinology & Metabolism, 23
KF Petersen (2007)
12587Proc Natl Acad Sci USA, 104
B. Fauser, B. Tarlatzis, R. Rebar, R. Legro, A. Balen, R. Lobo, E. Carmina, Jeffrey Chang, B. Yıldız, J. Laven, J. Boivin, F. Petraglia, C. Wijeyeratne, R. Norman, A. Dunaif, S. Franks, R. Wild, D. Dumesic, K. Barnhart (2012)
Consensus on women's health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group.Fertility and sterility, 97 1
I. Wallace, M. McKinley, P. Bell, S. Hunter (2013)
Sex hormone binding globulin and insulin resistanceClinical Endocrinology, 78
Shen Tian, Xianhua Lin, Yimeng Xiong, Miao-E. Liu, Tian-tian Yu, M. Lv, Wei Zhao, Gu-feng Xu, G. Ding, Chenming Xu, M. Jin, Chun Feng, Yan-ting Wu, Ya-jing Tan, Qian Gao, Jian Zhang, Cheng Li, Jun Ren, Luyang Jin, Bin Chen, Hong Zhu, Xue-Ying Zhang, Song-chang Chen, Xin-Mei Liu, Ye Liu, Jun-Yu Zhang, Li Wang, Ping Zhang, Xiao-jun Chen, Li Jin, Xi Chen, Yicong Meng, Dan‐dan Wu, Hui Lin, Qian Yang, Cheng-liang Zhou, Xinzhu Li, Yiyao Wang, Yuqian Xiang, Zhi-wei Liu, Ling Gao, Luting Chen, Hong-Jie Pan, Rong Li, Fang-hong Zhang, Lanfeng Xing, Yi-Min Zhu, C. Klausen, P. Leung, Ju-xue Li, F. Sun, J. Sheng, He-feng Huang (2017)
Prevalence of Prediabetes Risk in Offspring Born to Mothers with HyperandrogenismEBioMedicine, 16
G. Abruzzese, M. Heber, S. Ferreira, L. Velez, R. Reynoso, O. Pignataro, A. Motta (2016)
Prenatal hyperandrogenism induces alterations that affect liver lipid metabolism.The Journal of endocrinology, 230 1
A Gambieri, L Patton, P Altieri, U Pagotto, C Pizzi, L Manzoli, R Pasquali (2012)
Polycystic ovary syndrome is a risk factor for type 2 diabetes: results from a long-term prospective studyDiabetes, 61
H. Jones, Victoria Sprung, C. Pugh, C. Daousi, Andrew Irwin, N. Aziz, Valerie Adams, Elizabeth Thomas, Jimmy Bell, G. Kemp, D. Cuthbertson (2012)
Polycystic ovary syndrome with hyperandrogenism is characterized by an increased risk of hepatic steatosis compared to nonhyperandrogenic PCOS phenotypes and healthy controls, independent of obesity and insulin resistance.The Journal of clinical endocrinology and metabolism, 97 10
J. Barry, Mallika Azizia, P. Hardiman (2014)
Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysisHuman Reproduction Update, 20
P. Moghetti, F. Tosi, R. Castello, Chiara Magnani, C. Negri, E. Brun, L. Furlani, M. Caputo, M. Muggeo (1996)
The insulin resistance in women with hyperandrogenism is partially reversed by antiandrogen treatment: evidence that androgens impair insulin action in women.The Journal of clinical endocrinology and metabolism, 81 3
A. Dunaif, Magaret Graf, J. Mandeli, Vimla Laumas, Areta Dobrjansky (1987)
Characterization of groups of hyperandrogenic women with acanthosis nigricans, impaired glucose tolerance, and/or hyperinsulinemia.The Journal of clinical endocrinology and metabolism, 65 3
A Dunaif (1997)
774Endocr Rev, 18
D. Macut, K. Tziomalos, I. Božić-Antić, J. Bjekić-Macut, I. Katsikis, E. Papadakis, Z. Andrić, D. Panidis (2016)
Non-alcoholic fatty liver disease is associated with insulin resistance and lipid accumulation product in women with polycystic ovary syndrome.Human reproduction, 31 6
N. Goodman, R. Cobin, W. Futterweit, J. Glueck, R. Legro, E. Carmina (2015)
AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS, AMERICAN COLLEGE OF ENDOCRINOLOGY, AND ANDROGEN EXCESS AND PCOS SOCIETY DISEASE STATE CLINICAL REVIEW: GUIDE TO THE BEST PRACTICES IN THE EVALUATION AND TREATMENT OF POLYCYSTIC OVARY SYNDROME--PART 1.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, 21 11
H. Li, X. Xu, X. Wang, X. Liao, L. Li, G. Yang, L. Gao (2016)
Free androgen index and Irisin in polycystic ovary syndromeJournal of Endocrinological Investigation, 39
F. Mário, S. Graff, P. Spritzer (2017)
Habitual physical activity is associated with improved anthropometric and androgenic profile in PCOS: a cross-sectional studyJournal of Endocrinological Investigation, 40
A. Dunaif (1997)
Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis.Endocrine reviews, 18 6
Guadalupe Navarro, Weiwei Xu, D. Jacobson, B. Wicksteed, Camille Allard, Guanyi Zhang, K. Gendt, Sung Kim, Hongju Wu, Haitao Zhang, G. Verhoeven, J. Katzenellenbogen, F. Mauvais-Jarvis (2016)
Extranuclear Actions of the Androgen Receptor Enhance Glucose-Stimulated Insulin Secretion in the Male.Cell metabolism, 23 5
Asieh Mansour (2016)
551EXCLI J, 15
A. Gambineri, L. Patton, P. Altieri, U. Pagotto, C. Pizzi, L. Manzoli, R. Pasquali (2012)
Polycystic Ovary Syndrome Is a Risk Factor for Type 2 DiabetesDiabetes, 61
Asieh Mansour, S. Hosseini, B. Larijani, M. Mohajeri-Tehrani (2016)
Nutrients as novel therapeutic approaches for metabolic disturbances in polycystic ovary syndromeEXCLI Journal, 15
A. Baranova, T. Tran, A. Afendy, Lei Wang, Amirhossein Shamsaddini, R. Mehta, V. Chandhoke, A. Birerdinc, Z. Younossi (2013)
Molecular signature of adipose tissue in patients with both Non-Alcoholic Fatty Liver Disease (NAFLD) and Polycystic Ovarian Syndrome (PCOS)Journal of Translational Medicine, 11
Stephen Robinson, D. Kiddy, S. Gelding, D. Willis, R. Niththyananthan, A. Bush, Desmond Johnston, Steve Franks (1993)
The relationship of insulin insensitivity to menstrual pattern in women with hyperandrogenism and polycystic ovariesClinical Endocrinology, 39
D. Dumesic, A. Akopians, V. Madrigal, E. Ramirez, D. Margolis, M. Sarma, Albert Thomas, T. Grogan, R. Haykal, T. Schooler, B. Okeya, D. Abbott, G. Chazenbalk (2016)
Hyperandrogenism Accompanies Increased Intra-Abdominal Fat Storage in Normal Weight Polycystic Ovary Syndrome Women.The Journal of clinical endocrinology and metabolism, 101 11
R. Rosenfield, R. Barnes, D. Ehrmann (1994)
Studies of the nature of 17-hydroxyprogesterone hyperresonsiveness to gonadotropin-releasing hormone agonist challenge in functional ovarian hyperandrogenism.The Journal of clinical endocrinology and metabolism, 79 6
E. Vassilatou (2014)
Nonalcoholic fatty liver disease and polycystic ovary syndrome.World journal of gastroenterology, 20 26
RL Rosenfield (1994)
1686JCEM, 79
E. Diamanti-Kandarakis, C. Kouli, K. Alexandraki, G. Spina (2004)
Failure of mathematical indices to accurately assess insulin resistance in lean, overweight, or obese women with polycystic ovary syndrome.The Journal of clinical endocrinology and metabolism, 89 3
L. Mannerås-Holm, H. Leonhardt, J. Kullberg, E. Jennische, A. Odén, G. Holm, M. Hellström, L. Lönn, G. Olivecrona, E. Stener-Victorin, M. Lönn (2011)
Adipose tissue has aberrant morphology and function in PCOS: enlarged adipocytes and low serum adiponectin, but not circulating sex steroids, are strongly associated with insulin resistance.The Journal of clinical endocrinology and metabolism, 96 2
G. Croston, L. Milan, K. Marschke, M. Reichman, M. Briggs (1997)
Androgen receptor-mediated antagonism of estrogen-dependent low density lipoprotein receptor transcription in cultured hepatocytes.Endocrinology, 138 9
T. McLaughlin, C. Lamendola, Alice Liu, F. Abbasi (2011)
Preferential fat deposition in subcutaneous versus visceral depots is associated with insulin sensitivity.The Journal of clinical endocrinology and metabolism, 96 11
Mei-Jou Chen, Han-Mo Chiu, Chi-Ling Chen, Wei-Shiung Yang, Yu‐Shih Yang, H. Ho (2010)
Hyperandrogenemia is independently associated with elevated alanine aminotransferase activity in young women with polycystic ovary syndrome.The Journal of clinical endocrinology and metabolism, 95 7
J Endocrinol Invest (2018) 41:383–388 https://doi.org/10.1007/s40618-017-0762-3 REVIEW Androgen excess and metabolic disorders in women with PCOS: beyond the body mass index 1 1 1 1 R. A. Condorelli · A. E. Calogero · M. Di Mauro · L. M. Mongioi’ · 1 1 1 R. Cannarella · G. Rosta · S. La Vignera Received: 27 June 2017 / Accepted: 13 September 2017 / Published online: 23 September 2017 © Italian Society of Endocrinology (SIE) 2017 Abstract Keywords PCOS · Insulin resistance · Obesity · Background Insulin resistance is a common feature among Hyperandrogenism women with polycystic ovary syndrome (PCOS), especially in those patients with hyperandrogenism and chronic ano- Abbreviations vulation. PCOS women are at risk for developing metabolic A Androstenedione syndrome, impaired glucose tolerance and type II diabetes AACE American Association of Clinical mellitus (DM II). Endocrinology Objective The aim of this review is to explore the exist- ACE American College of Endocrinology ing knowledge of the interplay between androgen excess, BMI Body mass index pancreatic β-cell function, non-alcoholic fatty liver disease DHEAS Dehydroepiandrosterone sulfate (NAFLD), intra-abdominal and subcutaneous (SC) abdomi-DHT Di-hydro-testosterone nal adipocytes in PCOS, providing a better comprehension DM II Type II diabetes mellitus of the molecular mechanisms of diabetologic interest. DNMT3 De novo methyl-transferase 3 Methods A comprehensive ME DLINE search was per- FFA Free
Journal of Endocrinological Investigation – Springer Journals
Published: Sep 23, 2017
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.