Anatomical and Optical Properties of Atrial Tissue: Search for a Suitable Animal Model

Anatomical and Optical Properties of Atrial Tissue: Search for a Suitable Animal Model The purpose of this study was to evaluate structural and optical properties of atrial tissue from common animal models and to compare it with human atria. We aimed to do this in a format that will be useful for development of better ablation tools and/or new means for visualizing atrial lesions. Human atrial tissue from clinically relevant age group was compared and contrasted with atrial tissue of large animal models commonly available for research purposes. These included pigs, sheep, dogs and cows. The presented data include area measurements of smooth atrial surface available for ablation and estimates of thickness of collagen and muscle for five different species. We also described methods to quantify presence of collagen and overall thickness of atrial wall. Provided information enables placement of atrial lesions to locations with clinically relevant atrial wall thickness and macroscopic structure ultimately helping investigators to develop better ablation and imaging tools. It also highlights the impact of collagen thickness on optical measurements and lesion visualization. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cardiovascular Engineering and Technology Springer Journals

Anatomical and Optical Properties of Atrial Tissue: Search for a Suitable Animal Model

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Publisher
Springer US
Copyright
Copyright © 2017 by Biomedical Engineering Society
Subject
Engineering; Biomedical Engineering; Cardiology; Biomedicine, general
ISSN
1869-408X
eISSN
1869-4098
D.O.I.
10.1007/s13239-017-0329-7
Publisher site
See Article on Publisher Site

Abstract

The purpose of this study was to evaluate structural and optical properties of atrial tissue from common animal models and to compare it with human atria. We aimed to do this in a format that will be useful for development of better ablation tools and/or new means for visualizing atrial lesions. Human atrial tissue from clinically relevant age group was compared and contrasted with atrial tissue of large animal models commonly available for research purposes. These included pigs, sheep, dogs and cows. The presented data include area measurements of smooth atrial surface available for ablation and estimates of thickness of collagen and muscle for five different species. We also described methods to quantify presence of collagen and overall thickness of atrial wall. Provided information enables placement of atrial lesions to locations with clinically relevant atrial wall thickness and macroscopic structure ultimately helping investigators to develop better ablation and imaging tools. It also highlights the impact of collagen thickness on optical measurements and lesion visualization.

Journal

Cardiovascular Engineering and TechnologySpringer Journals

Published: Sep 7, 2017

References

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