Analysis of the full-length genome of hepatitis A virus isolated in South America: heterogeneity and evolutionary constraints

Analysis of the full-length genome of hepatitis A virus isolated in South America: heterogeneity... Hepatitis A virus (HAV) is a hepatotropic member of the family Picornaviridae. Currently, the entire nucleotide sequence is available for only 26 HAV isolates. The complete genome sequence of genotype IA HAV from strains isolated in South America, where genotype IA is the most prevalent genotype, remains unknown. In this study, the complete nucleotide sequence was determined for a genotype IA HAV isolate recovered from a Uruguayan patient (HAV5). Phylogenetic analysis performed using HAV5 and all available full-length IA genotype HAV strains revealed a high synonymous substitution rate throughout the HAV polyprotein. The results of these studies revealed strong selection against amino acid replacements along the HAV polyprotein and may explain, at least in part, the presence of a single HAV serotype. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Analysis of the full-length genome of hepatitis A virus isolated in South America: heterogeneity and evolutionary constraints

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Publisher
Springer Journals
Copyright
Copyright © 2008 by Springer-Verlag
Subject
Biomedicine; Infectious Diseases; Medical Microbiology ; Virology
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-008-0151-5
Publisher site
See Article on Publisher Site

Abstract

Hepatitis A virus (HAV) is a hepatotropic member of the family Picornaviridae. Currently, the entire nucleotide sequence is available for only 26 HAV isolates. The complete genome sequence of genotype IA HAV from strains isolated in South America, where genotype IA is the most prevalent genotype, remains unknown. In this study, the complete nucleotide sequence was determined for a genotype IA HAV isolate recovered from a Uruguayan patient (HAV5). Phylogenetic analysis performed using HAV5 and all available full-length IA genotype HAV strains revealed a high synonymous substitution rate throughout the HAV polyprotein. The results of these studies revealed strong selection against amino acid replacements along the HAV polyprotein and may explain, at least in part, the presence of a single HAV serotype.

Journal

Archives of VirologySpringer Journals

Published: Aug 1, 2008

References

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