A high performance liquid chromatography with ultraviolet detection was proposed for the separation and determination of relative substances in industrial arbutin and its synthetical intermediates 4-acetoxyphenol (ATP) and arbutin pentaacetate (ABPA). Liquid chromatography–mass spectrometry was used for further confirmation of these relative substances. As relative impurities, hydroquione (HQ) and 1,4-diacetoxybenzene (DATB) in industrial ATP, HQ, ATP, and DATB in industrial ABPA, and HQ, ATP, DATB, and ABPA in industrial arbutin were, respectively, quantified. As the results showed, the linearity of standard curves was excellent with relative coefficients of over 0.999 for all the detected components, and the intra- and inter-day precisions of impurities determination were satisfactory, with relative standard deviations of not more than 4.0 %. The distribution and transfer of related substances were elucidated in the synthesis process of arbutin. The established HPLC method not only has great potential in quality control of arbutin but can also be used to instruct the optimization of the synthesis procedure.
Research on Chemical Intermediates – Springer Journals
Published: May 8, 2013
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera