Ann Surg Oncol (2017) 24:2744–2751 DOI 10.1245/s10434-017-5975-3 OR IG INA L A R TIC L E – PA NC REATIC TU MO RS Analysis of Perioperative Chemotherapy in Resected Pancreatic Cancer: Identifying the Number and Sequence of Chemotherapy Cycles Needed to Optimize Survival 1 2 1 1 Irene Epelboym, MD , Mazen S. Zenati, MD, PhD , Ahmad Hamad, MD , Jennifer Steve, BS , Kenneth K. Lee, 1 3 1 1 1 MD , Nathan Bahary, MD, PhD , Melissa E. Hogg, MD , Herbert J. Zeh, MD , and Amer H. Zureikat, MD 1 2 Division of Surgical Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA; Department of Surgery and Epidemiology, University of Pittsburgh, Pittsburgh, PA; Department of Medical Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA ABSTRACT MVA (P \ 0.0001), tumor stage [hazard ratio (HR) 1.35], Purpose. Receipt of 6 cycles of adjuvant chemotherapy LNR (HR 4.3), and R1 margins (HR 1.77) were associated (AC) is standard of care in pancreatic cancer (PC). with increased hazard of death. Compared with 6 cycles Neoadjuvant chemotherapy (NAC) is increasingly utilized; AC, receipt of 0 cycles [HR 3.57, conﬁdence interval (CI) however, optimal number of cycles needed alone
Annals of Surgical Oncology – Springer Journals
Published: Jul 5, 2017
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