We amplified gag sequences from 66 individuals infected with HIV-1 CRF07_BC during 2003–2005 in the Xinjiang region of China. A novel deletion of 7aa (including a KELY motif) in the central region of the CRF07_BC gag p6 domain was detected, which has not been reported in other HIV-1 subtypes. Further deletions of up to 13aa (including KQE and KELY motifs) was also found in this domain, representing the biggest natural deletion up to now. Moreover, the CD4 + count and viral load level indicated that 1–13aa deletions in CRF07_BC gag p6 do not have a significant effect on viral replication and fitness.
Archives of Virology – Springer Journals
Published: Aug 1, 2007
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