Access the full text.
Sign up today, get DeepDyve free for 14 days.
(1990)
Genetic Data Analysis, Sunderland, Mass.: Sinauer
B.S. Weir (1990)
Genetic Data Analysis
(1983)
Statistical Methods for Analyzing Gene Frequencies in Natural Populations
G. Livshits, E. Kobyliansky (1984)
Biochemical heterozygosity as a predictor of developmental homeostasis in manAnnals of Human Genetics, 48
F. Aiala, J. Kaiger (1988)
Sovremennaya genetika
V.A. Spitsyn, E.B. Tsybikova, R.K. Agapova (1996)
The Effect of Genetic Factors on the Reaction to Surgery in Patients with Lung CarcinomaGenetika, 32
Altukhov IuP, Kurbatova Ol, Botvin'ev Ok, A. Ki, Malinina Tv (1981)
[Genetic markers and diseases: the genetic, anthropometric and clinical characteristics of children with acute pneumonia]., 17
Y. Dubrova, Y. Altukhov, A.N. Kucher, K.M. Ikramov (1988)
Heterozygosity in Biochemical and Immunological Gene Markers and Variation in Morphological and Physiological Traits in HumansGenetika, 24
G. Dahlberg (1948)
Genetics of human populations.Advances in genetics, 35 2
(2000)
Phenotypes of Blood Proteins and Efficiency of Treatment of Pulmonary Tuberculosis Patients, Vestn
Dubrova IuE, Altukhov IuP, Kucher An, Ikramov Km (1988)
The heterozygosity for the biochemical and immunological markers of genes and the variability of morphophysiological traits in man, 24
I. Bogadel'nikova, A. Sergeev, R. Agapova, M. Perel'man (2000)
[Blood protein phenotypes and effectiveness of the treatment of patients with pulmonary tuberculosis].Vestnik Rossiiskoi akademii meditsinskikh nauk, 3
Altukhov IuP, Kurbatova Ol (1990)
The problem of the adaptive norm in human populations, 26
Spintsyn Va, Tsybikova Eb, Agapova Rk, Afanas'eva Is, Perel'man Mi, Bochkov Np (1996)
Effect of hereditary factors on tolerance for surgical treatment in patients with lung cancer, 32
(1988)
Sovremennaya genetika (Modern Genetics)
Iu Altukhov, O. Kurbatova (1990)
[The problem of the adaptive norm in human populations].Genetika, 26 4
Y. Altukhov, O.L. Kurbatova, O.K. Botvin'ev (1981)
Genetic Markers and Disorders: Genetic, Anthropometric, and Clinical Peculiarities of Children with Acute PneumoniaGenetika, 17
Heterozygosity at nine genetic loci (PI, TF, PGM1, ACP1, HP, GC, GLO1, C3, and ESD) was analyzed in pulmonary tuberculosis patients with good (group 1, N= 71) and poor (group 2, N= 35) response to treatment. The observed heterozygosities were compared with the expected values, which were calculated from allele frequencies in a control sample of healthy individuals (N= 328 with all but one locus and 78 with ESD) according to Hardy–Weinberg expectations. The analysis showed that the observed heterozygosities g l of patients significantly differed from the expected values h lin the case of four loci (GC, PI, C3, and ACP1). The observed heterozygosity was higher than expected in three cases (PI, C3, and ACP1) and lower then expected (GC) in one case. When data on each individual locus were compared using Fisher's exact test, both groups of patients proved to significantly differ (P F< 0.05) from the control group in the same four loci. No difference in observed heterozygosity was detected between the two groups of patients. The mean expected heterozygosity was h¯= 0.386 ± 0.00674; the mean observed heterozygosity was g¯ = 0.415 ± 0.02 in group 1, g¯ = 0.402 ± 0.026 in group 2, and g¯ = 0.371 ± 0.00955 in the control group. The ttest did not reveal a significant difference between the mean values of expected observed heterozygosities. Heterozygosity at individual loci, rather than mean heterozygosity, was proposed as an integral nonspecific indicator of the genetic control of a disease, because the former directly implicates individual marker loci in the development of a disorder, whereas effects of individual loci may eliminate each other when mean heterozygosity is computed. Based on the results obtained, a genetic control was assumed for the development of the tuberculosis process in the lungs.
Russian Journal of Genetics – Springer Journals
Published: Oct 16, 2004
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.