Analysis of Allelic Association: Estimation of the Power of the TDT

Analysis of Allelic Association: Estimation of the Power of the TDT Analysis of allelic associations is an increasingly more widely used approach to fine mapping of genes of various diseases. To interpret the results correctly, it is necessary to estimate the power of the statistical test used. The principle of the analysis of associations and testing of hypothesis are described, and analytically obtained estimates of the power of the transmission disequilibrium test (TDT), one of the most popular methods of analysis of allelic associations, are presented. These estimates are applicable to arbitrary models of inheritance formulated in terms of genotypic relative risk. The proposed method is illustrated by analysis of the associations of idiopathic scoliosis and aggrecan gene alleles. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Genetics Springer Journals

Analysis of Allelic Association: Estimation of the Power of the TDT

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Publisher
Kluwer Academic Publishers-Plenum Publishers
Copyright
Copyright © 2003 by MAIK “Nauka/Interperiodica”
Subject
Biomedicine; Human Genetics
ISSN
1022-7954
eISSN
1608-3369
D.O.I.
10.1023/A:1025343226007
Publisher site
See Article on Publisher Site

Abstract

Analysis of allelic associations is an increasingly more widely used approach to fine mapping of genes of various diseases. To interpret the results correctly, it is necessary to estimate the power of the statistical test used. The principle of the analysis of associations and testing of hypothesis are described, and analytically obtained estimates of the power of the transmission disequilibrium test (TDT), one of the most popular methods of analysis of allelic associations, are presented. These estimates are applicable to arbitrary models of inheritance formulated in terms of genotypic relative risk. The proposed method is illustrated by analysis of the associations of idiopathic scoliosis and aggrecan gene alleles.

Journal

Russian Journal of GeneticsSpringer Journals

Published: Oct 7, 2004

References

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