Anakinra

Anakinra Reactions 1704, p33 - 2 Jun 2018 Injection site reactions: case report A 78-year-old woman developed injection site reactions during treatment of chronic calcium pyrophosphate arthritis with anakinra [duration of treatment to reaction onset and outcome not stated]. The woman had microscopically proven chronic calcium pyrophosphate arthritis for 10 years. She was initially treated with colchicine and prednisone, but no improvement was noted. Mild response was noted with methotrexate therapy, but it was discontinued due to unspecified adverse events. Thereafter, her treatment was started with SC anakinra 100 mg/day. Initially, a good response was noted, but later she developed injection site reactions. Her anakinra treatment was stopped and tocilizumab was started for her underlying condition. Her arthritis subsided with a significantly reduced joint pain and normalisation of acute phase reactants without any adverse events. Author comment: "[A]nakinra at 100 mg/day subcutaneously was initiated. She initially reported a good response, but the drug was later stopped due to injection site reactions." Quilis N, et al. Interleukin-6 pathway blockade as an option for managing refractory cases of crystal arthritis: Two cases report. Joint Bone Spine 85: 377-378, No. 3, May 2018. Available from: URL: http://doi.org/10.1016/ j.jbspin.2017.04.008 - Spain 803323654 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Anakinra

Reactions Weekly , Volume 1704 (1) – Jun 2, 2018
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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
D.O.I.
10.1007/s40278-018-46676-5
Publisher site
See Article on Publisher Site

Abstract

Reactions 1704, p33 - 2 Jun 2018 Injection site reactions: case report A 78-year-old woman developed injection site reactions during treatment of chronic calcium pyrophosphate arthritis with anakinra [duration of treatment to reaction onset and outcome not stated]. The woman had microscopically proven chronic calcium pyrophosphate arthritis for 10 years. She was initially treated with colchicine and prednisone, but no improvement was noted. Mild response was noted with methotrexate therapy, but it was discontinued due to unspecified adverse events. Thereafter, her treatment was started with SC anakinra 100 mg/day. Initially, a good response was noted, but later she developed injection site reactions. Her anakinra treatment was stopped and tocilizumab was started for her underlying condition. Her arthritis subsided with a significantly reduced joint pain and normalisation of acute phase reactants without any adverse events. Author comment: "[A]nakinra at 100 mg/day subcutaneously was initiated. She initially reported a good response, but the drug was later stopped due to injection site reactions." Quilis N, et al. Interleukin-6 pathway blockade as an option for managing refractory cases of crystal arthritis: Two cases report. Joint Bone Spine 85: 377-378, No. 3, May 2018. Available from: URL: http://doi.org/10.1016/ j.jbspin.2017.04.008 - Spain 803323654 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704

Journal

Reactions WeeklySpringer Journals

Published: Jun 2, 2018

References

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