An Update on the Management of Anaphylaxis

An Update on the Management of Anaphylaxis Purpose of review To highlight the latest evidence supporting management recommenda- tions in anaphylaxis and discuss the implications for further research in anaphylaxis management. Recent findings The acute management of anaphylaxis is largely centered on resuscitation and administration of epinephrine. There is little evidence to support the use of antihis- tamines and corticosteroids in the acute management of anaphylaxis. Summary Anaphylaxis is an acute, systemic, potentially life-threatening reaction caused by the release of mast cell and basophil mediators that could lead to distributive shock. Anaphylaxis is associated with increased healthcare utilization and costs. The definition of anaphylaxis is largely based on clinical criteria with no validated biomarker confirming the diagnosis. Long-term follow-up is recommended to identify triggers and co-factors of anaphylaxis. Further, this helps to establish a plan for trigger avoidance and emergency action plan to manage subsequent episodes. Given the significant morbidity and mortality associated with this diagnosis, high quality randomized controlled studies are lacking to support management decisions in anaphylaxis. Introduction Anaphylaxis is an acute, systemic, potentially life- mediators that could lead to distributive shock [4]. The threatening reaction that often results in emergency de- lifetime prevalence of anaphylaxis is estimated between partment visits and hospital admissions http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Treatment Options in Allergy Springer Journals

An Update on the Management of Anaphylaxis

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Publisher
Springer International Publishing
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Allergology; General Practice / Family Medicine
eISSN
2196-3053
D.O.I.
10.1007/s40521-018-0167-3
Publisher site
See Article on Publisher Site

Abstract

Purpose of review To highlight the latest evidence supporting management recommenda- tions in anaphylaxis and discuss the implications for further research in anaphylaxis management. Recent findings The acute management of anaphylaxis is largely centered on resuscitation and administration of epinephrine. There is little evidence to support the use of antihis- tamines and corticosteroids in the acute management of anaphylaxis. Summary Anaphylaxis is an acute, systemic, potentially life-threatening reaction caused by the release of mast cell and basophil mediators that could lead to distributive shock. Anaphylaxis is associated with increased healthcare utilization and costs. The definition of anaphylaxis is largely based on clinical criteria with no validated biomarker confirming the diagnosis. Long-term follow-up is recommended to identify triggers and co-factors of anaphylaxis. Further, this helps to establish a plan for trigger avoidance and emergency action plan to manage subsequent episodes. Given the significant morbidity and mortality associated with this diagnosis, high quality randomized controlled studies are lacking to support management decisions in anaphylaxis. Introduction Anaphylaxis is an acute, systemic, potentially life- mediators that could lead to distributive shock [4]. The threatening reaction that often results in emergency de- lifetime prevalence of anaphylaxis is estimated between partment visits and hospital admissions

Journal

Current Treatment Options in AllergySpringer Journals

Published: Apr 20, 2018

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