An Update on Calciphylaxis

An Update on Calciphylaxis Am J Clin Dermatol https://doi.org/10.1007/s40257-018-0361-x REVIEW ARTICLE 1 1 • • Jose ´ Alberto Garcı ´a-Lozano Jorge Ocampo-Candiani Sylvia Aide Mart´ ınez- 1 1 Cabriales Vero ´ nica Garza-Rodrı ´guez Springer International Publishing AG, part of Springer Nature 2018 Abstract Calciphylaxis, also known as calcific uremic arteriolopathy and uremic small artery disease with medial Key Points wall calcification and intimal hyperplasia, is a multifacto- rial cutaneous vascular disease characterized by chronic, Calciphylaxis is a multifactorial cutaneous vascular painful, non-healing wounds that occur frequently in disease characterized by chronic, painful, non- patients with chronic kidney disease, predominantly in healing wounds that occur frequently in patients with those with end-stage renal disease. The pathogenesis chronic kidney disease. remains unclear, and the development of calciphylaxis Histological confirmation is recommended and lesions depends on medial calcification, intimal fibrosis of remains the gold standard for definitive diagnosis; arterioles and thrombotic occlusion. Despite an increase in however, in cases where there is a high clinical reports of calciphylaxis in the literature and clinical suspicion of calciphylaxis, prompt aggressive recognition of demographic characteristics and risk factors treatment should be initiated and histological associated with calciphylaxis, it remains a poorly under- confirmation can be reserved. stood disease http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Clinical Dermatology Springer Journals
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Publisher
Springer International Publishing
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Dermatology; Pharmacotherapy; Pharmacology/Toxicology
ISSN
1175-0561
eISSN
1179-1888
D.O.I.
10.1007/s40257-018-0361-x
Publisher site
See Article on Publisher Site

Abstract

Am J Clin Dermatol https://doi.org/10.1007/s40257-018-0361-x REVIEW ARTICLE 1 1 • • Jose ´ Alberto Garcı ´a-Lozano Jorge Ocampo-Candiani Sylvia Aide Mart´ ınez- 1 1 Cabriales Vero ´ nica Garza-Rodrı ´guez Springer International Publishing AG, part of Springer Nature 2018 Abstract Calciphylaxis, also known as calcific uremic arteriolopathy and uremic small artery disease with medial Key Points wall calcification and intimal hyperplasia, is a multifacto- rial cutaneous vascular disease characterized by chronic, Calciphylaxis is a multifactorial cutaneous vascular painful, non-healing wounds that occur frequently in disease characterized by chronic, painful, non- patients with chronic kidney disease, predominantly in healing wounds that occur frequently in patients with those with end-stage renal disease. The pathogenesis chronic kidney disease. remains unclear, and the development of calciphylaxis Histological confirmation is recommended and lesions depends on medial calcification, intimal fibrosis of remains the gold standard for definitive diagnosis; arterioles and thrombotic occlusion. Despite an increase in however, in cases where there is a high clinical reports of calciphylaxis in the literature and clinical suspicion of calciphylaxis, prompt aggressive recognition of demographic characteristics and risk factors treatment should be initiated and histological associated with calciphylaxis, it remains a poorly under- confirmation can be reserved. stood disease

Journal

American Journal of Clinical DermatologySpringer Journals

Published: May 28, 2018

References

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