OBES SURG (2017) 27:3215–3222 DOI 10.1007/s11695-017-2743-1 ORIGINAL CONTRIBUTIONS An Optimized IES Method and Its Inhibitory Effects and Mechanisms on Food Intake and Body Weight in Diet-Induced Obese Rats: IES for Obesity 1,2 1,3 4 1,3 Xinyue Wan & Jieyun Yin & Robert Foreman & Jiande D. Z. Chen Published online: 25 May 2017 Springer Science+Business Media New York 2017 Abstract and accelerated intestinal transit (p <0.05). (5) IESincreased Purpose This paper aims to optimize stimulation parameters both fasting and postprandial plasma levels of GLP-1 but not and durations for intestinal electrical stimulation (IES) and to ghrelin. explore the effects and mechanisms of chronic IES with opti- Conclusion Twelve-hour daily IES using optimized stimula- mized methodology in obesity rats. tion parameters reduces food intake and body weight in DIO Materials and Methods Sixteen diet-induced obese (DIO) rats rats by altering gastrointestinal motility and GLP-1. The IES were tested for food intake with four different sets of IES methodology derived in this study may have a therapeutic parameters each lasting 1 week. Then, another 12 DIO rats potential for obesity. were used to test the effect of IES on food intake with different . . stimulation durations. Finally, 16 DIO rats
Obesity Surgery – Springer Journals
Published: May 25, 2017
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