An Optimized IES Method and Its Inhibitory Effects and Mechanisms on Food Intake and Body Weight in Diet-Induced Obese Rats: IES for Obesity

An Optimized IES Method and Its Inhibitory Effects and Mechanisms on Food Intake and Body Weight... OBES SURG (2017) 27:3215–3222 DOI 10.1007/s11695-017-2743-1 ORIGINAL CONTRIBUTIONS An Optimized IES Method and Its Inhibitory Effects and Mechanisms on Food Intake and Body Weight in Diet-Induced Obese Rats: IES for Obesity 1,2 1,3 4 1,3 Xinyue Wan & Jieyun Yin & Robert Foreman & Jiande D. Z. Chen Published online: 25 May 2017 Springer Science+Business Media New York 2017 Abstract and accelerated intestinal transit (p <0.05). (5) IESincreased Purpose This paper aims to optimize stimulation parameters both fasting and postprandial plasma levels of GLP-1 but not and durations for intestinal electrical stimulation (IES) and to ghrelin. explore the effects and mechanisms of chronic IES with opti- Conclusion Twelve-hour daily IES using optimized stimula- mized methodology in obesity rats. tion parameters reduces food intake and body weight in DIO Materials and Methods Sixteen diet-induced obese (DIO) rats rats by altering gastrointestinal motility and GLP-1. The IES were tested for food intake with four different sets of IES methodology derived in this study may have a therapeutic parameters each lasting 1 week. Then, another 12 DIO rats potential for obesity. were used to test the effect of IES on food intake with different . . stimulation durations. Finally, 16 DIO rats http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Obesity Surgery Springer Journals

An Optimized IES Method and Its Inhibitory Effects and Mechanisms on Food Intake and Body Weight in Diet-Induced Obese Rats: IES for Obesity

Loading next page...
 
/lp/springer_journal/an-optimized-ies-method-and-its-inhibitory-effects-and-mechanisms-on-PoNGcK06Dn
Publisher
Springer US
Copyright
Copyright © 2017 by Springer Science+Business Media New York
Subject
Medicine & Public Health; Surgery
ISSN
0960-8923
eISSN
1708-0428
D.O.I.
10.1007/s11695-017-2743-1
Publisher site
See Article on Publisher Site

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches

$49/month

Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.

$588

$360/year

billed annually
Start Free Trial

14-day Free Trial