An improved procedure for the synthesis of 2-morpholinoethanamine

An improved procedure for the synthesis of 2-morpholinoethanamine 2-Morpholinoethanamine is prepared rapidly mainly in aqueous conditions from inexpensive and commercially accessible starting materials. The process development of an effective synthetic route by utilizing morpholine as the starting material via Michael addition, hydrazinolysis, and Curtius rearrangements was undertaken. The optimal conditions were selected in the experiments. The total yield was 81.8% and it was a convenient process. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

An improved procedure for the synthesis of 2-morpholinoethanamine

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Publisher
Springer Netherlands
Copyright
Copyright © 2010 by Springer Science+Business Media B.V.
Subject
Chemistry; Inorganic Chemistry ; Physical Chemistry ; Catalysis
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-010-0163-0
Publisher site
See Article on Publisher Site

Abstract

2-Morpholinoethanamine is prepared rapidly mainly in aqueous conditions from inexpensive and commercially accessible starting materials. The process development of an effective synthetic route by utilizing morpholine as the starting material via Michael addition, hydrazinolysis, and Curtius rearrangements was undertaken. The optimal conditions were selected in the experiments. The total yield was 81.8% and it was a convenient process.

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Aug 17, 2010

References

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