Short Communications Incorporating Mouse Genome Mammalian Genome 12, 867–868 (2001). © Springer-Verlag New York Inc. 2001 DOI: 10.1007/s00335-001-2065-3 An F344 rat congenic for BB/DP rat-derived diabetes susceptibility loci Iddm1 and Iddm2 Lars Hornum, Dorthe Lundsgaard, Helle Markholst Hagedorn Research Institute, Niels Steensens Vej 6, DK-2820 Gentofte, Denmark Received: 28 February 2001 / Accepted: 5 July 2001 The diabetes-prone BB rat (BB/DP) spontaneously develops an diabetic at this age (p << 0.001), although kept under the same insulin-dependent diabetes resembling human Type 1 diabetes specific pathogen-free conditions. Insulitis was not detected dp u (previously named IDDM). As in Type 1 diabetes, the insulin- among four F344.Lyp RT1 congenic rats at the age of 120 days. producing b-cells of the islets of Langerhans are targets for auto- This clearly demonstrates that loci outside Iddm1 and -2 protect immune destruction (Crisa et al. 1992). Two major diabetes sus- ceptibility genes have been genetically positioned from this model: Iddm1 (Lyp) on rat chromosome (Chr) 4 and Iddm2 (RT1) on rat Chr 20 (Colle et al. 1981; Jacob et al. 1992), but several studies have defined additional loci involved in diabetes development (Klo ¨ ting et al. 1995, 1998; Klo ¨ ting and Kovacs
Mammalian Genome – Springer Journals
Published: Apr 20, 2014
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