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E. Colle, R. Guttmann, T. Seemayer (1981)
Spontaneous diabetes mellitus syndrome in the rat. I. Association with the major histocompatibility complexThe Journal of Experimental Medicine, 154
R. Steen, A. Kwitek-Black, Christopher Glenn, J. Gullings-Handley, W. Etten, O. Atkinson, D. Appel, S. Twigger, Melanie Muir, Tim Mull, M. Granados, Mushira Kissebah, Kerri Russo, Robbin Crane, M. Popp, M. Peden, T. Matise, Donna Brown, Jian Lu, S. Kingsmore, P. Tonellato, S. Rozen, D. Slonim, Peter Young, M. Knoblauch, A. Provoost, Detlev Ganten, S. Colman, J. Rothberg, E. Lander, H. Jacob (1999)
A high-density integrated genetic linkage and radiation hybrid map of the laboratory rat.Genome research, 9 6
L. Hornum, H. Markholst (1999)
Genetic map of the lymphopenia region on rat chromosome 4.Transplantation proceedings, 31 3
L. Klaff, G. Koike, Jianjie Jiang, Yanling Wang, S. Bieg, A. Pettersson, E. Lander, H. Jacob, Å. Lernmark (1999)
BB rat diabetes susceptibility and body weight regulation genes colocalize on Chromosome 2Mammalian Genome, 10
I. Klöting, P. Kovacs (1998)
Phenotypic differences between diabetes‐prone BB rat sublines cosegregate with loci on chromosomes X and 10IUBMB Life, 45
Laura Crisa, J. Mordes, Aldo Rossini (1992)
Autoimmune diabetes mellitus in the BB rat.Diabetes/metabolism reviews, 8 1
E. Wakeland, L. Morel, K. Achey, M. Yui, Jeff Longmate (1997)
Speed congenics: a classic technique in the fast lane (relatively speaking).Immunology today, 18 10
M. Jackerott, L. Hornum, B. Andreasen, H. Markholst (1997)
Segregation of autoimmune type 1 diabetes in a cross between diabetic BB and brown Norway rats.Journal of autoimmunity, 10 1
I. Klöting, L. Vogt, T. Serikawa (1995)
Locus on chromosome 18 cosegregates with diabetes in the BB/OK rat subline.Diabete & metabolisme, 21 5
I. Klöting, S. Schmidt, P. Kovacs (1998)
Mapping of novel genes predisposing or protecting diabetes development in the BB/OK rat.Biochemical and biophysical research communications, 245 2
H. Jacob, A. Pettersson, Deborah Wilson, Y. Mao, Å. Lernmark, E. Lander (1992)
Genetic dissection of autoimmune type I diabetes in the BB ratNature Genetics, 2
A. Martin, E. Blankenhorn, M. Maxson, M. Zhao, J. Leif, J. Mordes, D. Greiner (1999)
Non-major histocompatibility complex-linked diabetes susceptibility loci on chromosomes 4 and 13 in a backcross of the DP-BB/Wor rat to the WF rat.Diabetes, 48 1
(1999)
Non - major histocompatibility complex - linked
Short Communications Incorporating Mouse Genome Mammalian Genome 12, 867–868 (2001). © Springer-Verlag New York Inc. 2001 DOI: 10.1007/s00335-001-2065-3 An F344 rat congenic for BB/DP rat-derived diabetes susceptibility loci Iddm1 and Iddm2 Lars Hornum, Dorthe Lundsgaard, Helle Markholst Hagedorn Research Institute, Niels Steensens Vej 6, DK-2820 Gentofte, Denmark Received: 28 February 2001 / Accepted: 5 July 2001 The diabetes-prone BB rat (BB/DP) spontaneously develops an diabetic at this age (p << 0.001), although kept under the same insulin-dependent diabetes resembling human Type 1 diabetes specific pathogen-free conditions. Insulitis was not detected dp u (previously named IDDM). As in Type 1 diabetes, the insulin- among four F344.Lyp RT1 congenic rats at the age of 120 days. producing b-cells of the islets of Langerhans are targets for auto- This clearly demonstrates that loci outside Iddm1 and -2 protect immune destruction (Crisa et al. 1992). Two major diabetes sus- ceptibility genes have been genetically positioned from this model: Iddm1 (Lyp) on rat chromosome (Chr) 4 and Iddm2 (RT1) on rat Chr 20 (Colle et al. 1981; Jacob et al. 1992), but several studies have defined additional loci involved in diabetes development (Klo ¨ ting et al. 1995, 1998; Klo ¨ ting and Kovacs
Mammalian Genome – Springer Journals
Published: Apr 20, 2014
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