An example of quality control of fine chemical intermediates: related impurity analysis of industrial phthalic anhydride by reversed-phase high-performance liquid chromatography

An example of quality control of fine chemical intermediates: related impurity analysis of... A reliable reversed-phase high-performance liquid chromatographic method has been developed for analysis of related impurities in industrial phthalic anhydride (PA). Maleic acid (hydrolysis product of maleic anhydride), phthalimide, and benzoic acid were separated from phthalic acid (Pa, hydrolysis product of PA) on a C18 column by gradient elution with acetonitrile and 0.1% (v/v) aqueous perchloric acid solution. This method is simple, sensitive, and accurate, and has been successfully applied to quality control of PA for industrial use. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

An example of quality control of fine chemical intermediates: related impurity analysis of industrial phthalic anhydride by reversed-phase high-performance liquid chromatography

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Publisher
Springer Netherlands
Copyright
Copyright © 2011 by Springer Science+Business Media B.V.
Subject
Chemistry; Inorganic Chemistry; Physical Chemistry; Catalysis
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-010-0234-2
Publisher site
See Article on Publisher Site

Abstract

A reliable reversed-phase high-performance liquid chromatographic method has been developed for analysis of related impurities in industrial phthalic anhydride (PA). Maleic acid (hydrolysis product of maleic anhydride), phthalimide, and benzoic acid were separated from phthalic acid (Pa, hydrolysis product of PA) on a C18 column by gradient elution with acetonitrile and 0.1% (v/v) aqueous perchloric acid solution. This method is simple, sensitive, and accurate, and has been successfully applied to quality control of PA for industrial use.

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Jan 14, 2011

References

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