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An epitope on the adenovirus fibre tail is common to all human subgroups

An epitope on the adenovirus fibre tail is common to all human subgroups A group specific linear epitope with the sequence -FNPVY- was detected in the tail region of the adenovirus fibre by using a monoclonal antibody (Mab) and selection with a hexapeptide phage expression library. A synthetic peptide with sequence DT YDTE from adenovirus type 2 (Ad2) was shown by preincubation with the Mab to block its binding to fibre. A biotinylated form of this peptide bound to the monomeric fibre and not to the dimeric and trimeric forms. On the other hand the monoclonal antibodies bound to the monomeric, dimeric and trimeric forms of the fibre. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

An epitope on the adenovirus fibre tail is common to all human subgroups

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References (16)

Publisher
Springer Journals
Copyright
Copyright © 2000 by Springer-Verlag/Wien
Subject
Legacy
ISSN
0304-8608
eISSN
1432-8798
DOI
10.1007/s007050050673
Publisher site
See Article on Publisher Site

Abstract

A group specific linear epitope with the sequence -FNPVY- was detected in the tail region of the adenovirus fibre by using a monoclonal antibody (Mab) and selection with a hexapeptide phage expression library. A synthetic peptide with sequence DT YDTE from adenovirus type 2 (Ad2) was shown by preincubation with the Mab to block its binding to fibre. A biotinylated form of this peptide bound to the monomeric fibre and not to the dimeric and trimeric forms. On the other hand the monoclonal antibodies bound to the monomeric, dimeric and trimeric forms of the fibre.

Journal

Archives of VirologySpringer Journals

Published: Apr 1, 2000

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