An environmental study on starch aerogel for drug delivery applications: effect of plant scale-up

An environmental study on starch aerogel for drug delivery applications: effect of plant scale-up Purpose The aim of this work is the evaluation and minimi- tion from bench to pilot scale induced a substantial reduction of zation, using a life cycle assessment approach, of the environ- the impacts on all the categories. On both scales, the analysis mental impacts of starch aerogel production on different scale made using midpoint categories showed that supercritical dry- plants. Aerogels are porous structures, which can be used as ing step strongly affected carcinogens and mineral extraction, carriers for delivery systems; they are obtained through a su- whereas alcogel production step strongly affected respiratory percritical drying. The impacts related to the production of 1 g organics. Solutions aimed at minimizing these impacts were of starch aerogel on two different scales (vessel internal vol- proposed. The performed analysis, using both midpoint and umes equal to 0.5 and 5.2 L) were evaluated and compared. endpoint categories, allowed to identify the aerogel production The environmental impacts on an industrial scale plant were weak points and propose improved solutions. Conclusions Global emissions related to starch aerogel pro- also simulated. Methods All the quantities related to materials, energy con- duction were lowered passing from bench scale to pilot scale. sumption and emissions to http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The International Journal of Life Cycle Assessment Springer Journals

An environmental study on starch aerogel for drug delivery applications: effect of plant scale-up

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Publisher
Springer Journals
Copyright
Copyright © 2017 by Springer-Verlag GmbH Germany
Subject
Environment; Environment, general; Environmental Economics; Environmental Engineering/Biotechnology; Environmental Chemistry
ISSN
0948-3349
eISSN
1614-7502
D.O.I.
10.1007/s11367-017-1351-6
Publisher site
See Article on Publisher Site

Abstract

Purpose The aim of this work is the evaluation and minimi- tion from bench to pilot scale induced a substantial reduction of zation, using a life cycle assessment approach, of the environ- the impacts on all the categories. On both scales, the analysis mental impacts of starch aerogel production on different scale made using midpoint categories showed that supercritical dry- plants. Aerogels are porous structures, which can be used as ing step strongly affected carcinogens and mineral extraction, carriers for delivery systems; they are obtained through a su- whereas alcogel production step strongly affected respiratory percritical drying. The impacts related to the production of 1 g organics. Solutions aimed at minimizing these impacts were of starch aerogel on two different scales (vessel internal vol- proposed. The performed analysis, using both midpoint and umes equal to 0.5 and 5.2 L) were evaluated and compared. endpoint categories, allowed to identify the aerogel production The environmental impacts on an industrial scale plant were weak points and propose improved solutions. Conclusions Global emissions related to starch aerogel pro- also simulated. Methods All the quantities related to materials, energy con- duction were lowered passing from bench scale to pilot scale. sumption and emissions to

Journal

The International Journal of Life Cycle AssessmentSpringer Journals

Published: Jul 5, 2017

References

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